Table 2.
Predicted potential CD8 + T-cell epitopes of RVFV interacting with different MHC class I HLA-alleles.
| CD8 + T-cell epitopes | Combined score | Antigenicity score | Immunogenicity | MHC-I alleles | Position | Conservancy score |
|---|---|---|---|---|---|---|
| Nucleocapsid (N) | ||||||
| WLPVTGTTM | 0.8867 | 0.9328 | 0.16308 | HLA-C*12:03,HLA-B*15:02,HLA-C*14:02,HLA-C*03:03,HLA-C*07:02 | 125–133 | 99.39% |
| MMHPSFAGM | 1.1149 | 1.7017 | 0.00126 | HLA-B*15:02,HLA-C*14:02,HLA-B*15:01,HLA-C*03:03,HLA-B*35:01,HLA-A*02:06,HLA-C*12:03 | 144–152 | 99.39% |
| SRVINPNLR | 0.6389 | 1.0188 | 0.11864 | HLA-C*12:03,HLA-C*03:03,HLA-C*07:01,HLA-C*14:02,HLA-C*07:02 | 177–185 | 100.00% |
| Glycoprotein (G) | ||||||
| TMAGIAMTV | 1.2078 | 0.8376 | 0.08771 | HLA-A*02:06,HLA-A*02:01,HLA-C*12:03,HLA-A*68:02,HLA-C*03:03,HLA-C*14:02 | 130–138 | 100.00% |
| AVFALAPVV | 1.0052 | 0.7110 | 0.11816 | HLA-C*12:03,HLA-A*02:06,HLA-C*15:02,HLA-A*02:01,HLA-C*14:02 | 143–151 | 100.00% |
| LAVFALAPV | 0.8628 | 0.9445 | 0.1854 | HLA-C*12:03,HLA-C*03:03,HLA-A*02:06,HLA-A*68:02,HLA-C*15:02,HLA-C*14:02 | 142–150 | 100.00% |
| FALAPVVFA | 0.7907 | 1.0606 | 0.16707 | HLA-C*03:03,HLA-C*12:03,HLA-A*02:06,HLA-C*05:01,HLA-A*68:02,HLA-B*15:02 | 145–153 | 100.00% |
| VFALAPVVF | 1.7269 | 1.3111 | 0.08816 | HLA-C*03:03,HLA-A*23:01,HLA-C*14:02,HLA-C*12:03,HLA-A*24:02,HLA-B*15:02,HLA-C*07:02 | 144–152 | 100.00% |
| MAGIAMTVL | 0.82 | 0.7997 | 0.0746 | HLA-C*12:03,HLA-C*03:03,HLA-B*15:02,HLA-C*15:02,HLA-B*35:01 | 131–139 | 100.00% |
| RETMAGIAM | 1.5256 | 0.8666 | 0.04108 | HLA-B*40:01,HLA-C*03:03,HLA-C*12:03,HLA-B*40:02,HLA-B*15:02,HLA-C*07:02 | 128–136 | 100.00% |
| IAMTVLPAL | 1.0016 | 0.5100 | 0.02532 | HLA-C*12:03,HLA-C*03:03,HLA-C*14:02,HLA-A*02:06,HLA-B*15:02,HLA-B*35:01,HLA-A*02:01,HLA-C*15:02 | 134–142 | 100.00% |
| VCEVGVQAL | 0.7653 | 1.1196 | 0.071 | HLA-B*15:02,HLA-C*03:03,HLA-C*14:02,HLA-C*12:03,HLA-C*07:02 | 321–329 | 100.00% |
| RVEPCTTCI | 0.777 | 0.5474 | 0.00664 | HLA-C*05:01,HLA-C*12:03,HLA-C*03:03,HLA-C*15:02,HLA-A*32:01 | 475–483 | 100.00% |
| TAFIRWVYK | 1.382 | 0.6560 | 0.46351 | HLA-C*12:03,HLA-A*68:01,HLA-A*11:01,HLA-C*03:03,HLA-A*31:01,HLA-A*30:01,HLA-A*03:01,HLA-C*07:01,HLA-C*14:02 | 625–633 | 95.00% |
| IICLAILYK | 1.2334 | 1.4732 | 0.1232 | HLA-A*11:01,HLA-C*12:03,HLA-A*03:01,HLA-A*68:01,HLA-C*03:03,HLA-C*14:02 | 597–605 | 10.00% |
| AIICLAILY | 1.2533 | 1.3231 | 0.12082 | HLA-C*12:03,HLA-A*29:02,HLA-C*03:03,HLA-A*30:02,HLA-A*11:01 | 596–604 | 35.00% |
| LSSRRCHLV | 0.6673 | 1.2811 | 0.01885 | HLA-C*12:03,HLA-C*15:02,HLA-C*07:01,HLA-C*03:03,HLA-C*06:02 | 772–780 | 100.00% |
| RVFNCIDWV | 1.0863 | 1.7981 | 0.25241 | HLA-C*12:03,HLA-A*02:06,HLA-A*02:01,HLA-C*07:01,HLA-A*68:02 | 848–856 | 100.00% |
| ETSAEFSFV | 1.1516 | 1.9805 | 0.12215 | HLA-A*68:02,HLA-C*12:03,HLA-C*15:02,HLA-C*03:03,HLA-A*02:06 | 795–803 | 100.00% |
| FVVFERGSL | 1.1708 | 0.7552 | 0.20936 | HLA-C*03:03,HLA-B*15:02,HLA-C*12:03,HLA-C*14:02,HLA-B*35:03,HLA-A*68:02 | 973–981 | 97.50% |
| LRAPNLISY | 1.263 | 0.9951 | 0.00046 | HLA-C*12:03,HLA-C*03:03,HLA-C*07:01,HLA-C*07:02,HLA-C*14:02,HLA-B*14:02 | 948–956 | 35.00% |
| PRQGFLGEI | 0.5175 | 0.9779 | 0.18716 | HLA-C*12:03,HLA-C*07:01,HLA-C*03:03,HLA-C*14:02,HLA-C*06:02 | 924–932 | 97.50% |
| FTNWGSVSL | 1.2356 | 2.0756 | 0.03624 | HLA-B*15:02,HLA-C*03:03,HLA-C*15:02,HLA-B*39:01,HLA-C*12:03,HLA-A*02:06,HLA-A*68:02,HLA-C*14:02,HLA-B*35:03,HLA-C*07:01 | 882–890 | 100.00% |
| FEQCGGWGC | 0.9179 | 0.7089 | 0.17979 | HLA-C*12:03,HLA-C*03:03,HLA-B*15:02,HLA-C*08:02,HLA-B*40:01 | 815–823 | 100.00% |
| KGNRGVQAF | 1.2086 | 0.8800 | 0.04694 | HLA-C*05:01,HLA-C*07:02,HLA-C*12:03,HLA-C*14:02,HLA-B*15:02,HLA-A*32:01 | 994–1002 | 100.00% |
| YSCNAGARV | 0.7606 | 1.0814 | 0.10925 | HLA-C*12:03,HLA-C*15:02,HLA-C*07:01,HLA-C*14:02,HLA-C*06:02 | 1040–1048 | 100.00% |
| EVDFVGAAV | 0.5976 | 0.9494 | 0.25298 | HLA-C*05:01,HLA-C*12:03,HLA-A*68:02,HLA-C*08:02,HLA-C*14:02 | 1019–1027 | 97.50% |
| FFDWFSGLM | 0.5881 | 0.6472 | 0.21048 | HLA-C*12:03,HLA-B*15:02,HLA-C*14:02,HLA-C*08:02,HLA-C*07:01,HLA-B*35:01,HLA-C*04:01,HLA-C*06:02 | 1142–1150 | 100.00% |
| ALSIGLFFL | 1.3051 | 1.2128 | 0.26998 | HLA-A*02:01,HLA-A*02:06,HLA-C*03:03,HLA-B*15:02,HLA-C*12:03 | 1168–1176 | 97.50% |
| GLFFLLIYL | 1.2359 | 0.6126 | 0.24472 | HLA-A*02:01,HLA-C*14:02,HLA-C*12:03,HLA-A*02:06,HLA-B*15:02 | 1172–1180 | 100.00% |
| ILHFTVPEV | 1.2196 | 0.8591 | 0.2541 | HLA-C*14:02,HLA-A*02:01,HLA-C*12:03,HLA-A*02:06,HLA-C*03:03 | 1085–1093 | 100.00% |
| TILLICLYV | 1.1533 | 0.6223 | 0.05257 | HLA-C*12:03,HLA-A*02:06,HLA-C*15:02,HLA-A*02:01,HLA-C*14:02,HLA-A*68:02 | 1159–1167 | 97.50% |
| ILLICLYVA | 0.8389 | 0.5777 | 0.08838 | HLA-A*02:01,HLA-C*12:03,HLA-A*02:06,HLA-C*14:02,HLA-C*03:03 | 1160–1168 | 95.00% |
| FLLIYLGRT | 0.7428 | 1.1077 | 0.17512 | HLA-C*14:02,HLA-A*02:01,HLA-C*12:03,HLA-C*03:03,HLA-A*02:06 | 1175–1183 | 100.00% |
| KMWLAATKK | 1.5878 | 1.0998 | 0.04243 | HLA-A*03:01,HLA-C*14:02,HLA-C*12:03,HLA-A*11:01,HLA-A*31:01 | 1187–1195 | 100.00% |
| LYVALSIGL | 1.134 | 1.8044 | 0.01836 | HLA-C*14:02,HLA-C*03:03,HLA-C*12:03,HLA-B*15:02,HLA-C*07:02 | 1165–1173 | 97.50% |
| KTILLICLY | 1.9084 | 0.7398 | 0.09454 | HLA-C*12:03,HLA-B*58:01,HLA-A*29:02,HLA-A*30:02,HLA-A*01:01,HLA-A*32:01,HLA-C*03:03,HLA-C*14:02,HLA-B*57:01 | 1158–1166 | 97.50% |
| LLICLYVAL | 1.402 | 1.0546 | 0.03237 | HLA-C*03:03,HLA-A*02:01,HLA-A*02:06,HLA-B*15:02,HLA-C*14:02,HLA-C*12:03 | 1161–1169 | 97.50% |
| VALSIGLFF | 1.2362 | 0.9478 | 0.05047 | HLA-C*03:03,HLA-C*12:03,HLA-B*58:01,HLA-B*35:01,HLA-C*05:01,HLA-B*53:01,HLA-C*14:02 | 1167–1175 | 97.50% |
| LSIGLFFLL | 1.0775 | 0.6297 | 0.26902 | HLA-C*03:03,HLA-A*02:06,HLA-C*12:03,HLA-C*15:02,HLA-A*68:02,HLA-B*58:01,HLA-B*15:02 | 1169–1177 | 100.00% |