Table 3.
Predicted potential overlapping CD4 + T-cell epitopes of RVFV interacting with different MHC class II HLA-alleles.
| Overlapping CD4 + T-Cell Epitopes | MHC-II alleles | Antigenicity | Position |
|---|---|---|---|
| Nucleocapsid (N) | |||
| HMMHPSFAGMVDPSL | HLA-DRB1*0101,HLA-DRB1*0901,HLA-DRB1*0405,HLA-DQA1*0501/DQB1*0301,HLA-DRB1*0401,HLA-DRB1*0701 | 1.0025 | 143–157 |
| MMHPSFAGMVDPSLP | HLA-DRB1*01:01,HLA-DRB1*04:05,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*04:01,HLA-DRB1*09:01 | 0.9451 | 144–158 |
| LYLLQFSRVINPNLR | HLA-DRB1*01:01,HLA-DRB1*04:05,HLA-DRB1*07:01, HLA-DRB1*04:04,HLA DRB1*04:01,HLA-DRB5*01:01, HLA-DRB1*15:01,HLA-DPA1*01:03/DPB1*02:01, HLA-DRB1*11:01,HLA-DRB1*09:01 | 0.6108 | 171–185 |
| YLLQFSRVINPNLRG | HLA-DRB1*01:01,HLA-DRB1*04:05,HLA-DRB1*07:01,HLA-DRB1*04:04,HLA-DRB1*04:01,HLA-DRB5*01:01,HLA-DRB1*15:01,HLA-DRB1*09:01,HLA-DRB1*11:01 | 0.6286 | 172–186 |
| LLQFSRVINPNLRGR | HLA-DRB1*01:01,HLA-DRB1*04:05,HLA-DRB1*07:01,HLA-DRB1*04:04,HLA-DRB1*04:01,HLA-DRB5*01:01,HLA-DRB1*09:01 | 1.2501 | 173–187 |
| LQFSRVINPNLRGRT | HLA-DRB1*04:05,HLA-DRB1*01:01,HLA-DRB1*07:01,HLA-DRB1*04:04,HLA-DRB1*04:01,HLA-DRB5*01:01,HLA-DRB1*09:01 | 0.8316 | 174–188 |
| Glycoprotein (G) | |||
| TMAGIAMTVLPALAV | HLA-DRB1*01:01,HLA-DRB1*04:04,HLA-DQA1*05:01/DQB1*03:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*09:01,HLA-DRB1*07:01,HLA-DRB1*11:01 | 0.7438 | 130–144 |
| LPALAVFALAPVVFA | HLA-DRB1*01:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*15:01,HLA-DRB1*09:01,HLA-DRB1*04:04 | 0.7636 | 139–153 |
| PALAVFALAPVVFAE | HLA-DRB1*01:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*09:01,HLA-DRB1*15:01,HLA-DRB1*04:04 | 0.7211 | 140–154 |
| VLPALAVFALAPVVF | HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*01:01,HLA-DRB1*15:01,HLA-DRB1*12:01,HLA-DRB1*04:04 | 0.6372 | 138–152 |
| MTVLPALAVFALAPV | HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*01:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*04:04,HLA-DRB1*15:01,HLA-DRB1*12:01,HLA-DRB1*09:01, | 0.6143 | 136–150 |
| MAGIAMTVLPALAVF | HLA-DRB1*01:01,HLA-DRB1*04:04,HLA-DRB1*09:01,HLA-DQA1*01:02/DQB1*06:02,HLA-DRB1*07:01,HLA-DRB1*11:01, HLA-DQA1*05:01/DQB1*03:01 | 0.5647 | 131–145 |
| GIAMTVLPALAVFAL | HLA-DRB1*01:01,HLA-DRB1*04:04,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*09:01,HLA-DRB1*07:01, HLA-DRB1*11:01,HLA-DQA1*01:02/DQB1*06:02, HLA-DRB1*12:01 | 0.6562 | 133–147 |
| AGIAMTVLPALAVFA | HLA-DRB1*01:01,HLA-DRB1*04:04, HLA-DQA1*01:02/DQB1*06:02, HLA-DRB1*09:01,HLA-DQA1*05:01/DQB1*03:01,HLA-DRB1*07:01,HLA-DRB1*11:01, HLA-DRB1*12:01 | 0.5161 | 132–146 |
| NPLMWITAFIRWVYK | HLA-DRB5*01:01,HLA-DRB1*04:04,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*01:01,HLA-DRB1*15:01,HLA-DPA1*01/DPB1*04:01,HLA-DRB1*12:01 | 0.5045 | 619–633 |
| IICLAILYKVLKCLK | HLA-DRB1*11:01,HLA-DRB5*01:01,HLA-DRB1*01:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*15:01 | 0.5904 | 597–611 |
| AIICLAILYKVLKCL | HLA-DRB1*11:01,HLA-DRB5*01:01,HLA-DRB1*01:01,HLADPA1*03:01/DPB1*04:02,HLA-DRB1*15:01 | 0.5698 | 596–610 |
| SGSWNFFDWFSGLMS | HLA-DPA1*01:03/DPB1*02:01, HLA-DRB1*04:04,HLA-DRB1*01:01, HLA-DRB1*09:01,HLA-DRB1*07:01, HLA-DRB1*04:05 | 0.7241 | 1137–1151 |
| SWNFFDWFSGLMSWF | HLA-DRB1*01:01,HLA-DRB1*09:01,HLA-DRB1*07:01,HLA-DRB1*04:04, HLA-DRB1*04:05, HLA-DPA1*01:03/DPB1*02:01 | 0.5094 | 1139–1153 |
| GSWNFFDWFSGLMSW | HLA-DRB1*04:04,HLA-DRB1*01:01,HLA-DRB1*09:01,HLA-DRB1*07:01, HLA-DRB1*04:05, HLA-DPA1*01:03/DPB1*02:01 | 0.8838 | 1138–1152 |
| YVALSIGLFFLLIYL | HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*01/DPB1*04:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*01:01,HLA-DRB1*15:01,HLA-DQA1*01:01/DQB1*05:01,HLA-DPA1*02:01/DPB1*05:01 | 0.8703 | 1166–1180 |
| VALSIGLFFLLIYLG | HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*01/DPB1*04:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*01:01, HLA-DRB1*15:01,HLA-DQA1*01:01/DQB1*05:01,HLA-DPA1*02:01/DPB1*05:01,HLA-DRB1*11:01 | 0.9838 | 1167–1181 |
| CLYVALSIGLFFLLI | HLA-DPA1*01/DPB1*04:01, HLA-DPA1*02:01/DPB1*01:01, HLA-DPA1*02:01/DPB1*05:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DRB1*01:01, HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*07:01, HLA-DRB1*09:01 | 0.8330 | 1164–1178 |
| LYVALSIGLFFLLIY | HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*01/DPB1*04:01,HLA-DRB1*01:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*07:01,HLA-DPA1*02:01/DPB1*05:01,HLA-DQA1*01:01/DQB1*05:01,HLA-DRB1*15:01 | 0.8518 | 1165–1179 |
| ICLYVALSIGLFFLL | HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DRB1*07:01, HLA-DRB1*15:01,HLA-DRB1*09:01, HLA-DPA1*03:01/DPB1*04:02,HLA-DPA1*01/DPB1*04:01, HLA-DRB5*01:01, HLA-DPA1*02:01/DPB1*05:01,HLA-DRB1*04:05 | 1.0197 | 1163–1177 |
| LICLYVALSIGLFFL | HLA-DRB1*01:01,HLA-DRB1*07:01,HLA-DRB1*09:01,HLA-DRB1*15:01,HLA-DRB5*01:01,HLA-DRB1*04:05,HLA-DRB1*04:04,HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*11:01 | 1.0286 | 1162–1176 |
| ALSIGLFFLLIYLGR | HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*01/DPB1*04:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*01:01, HLA-DPA1*02:01/DPB1*05:01,HLA-DRB5*01:01,HLA-DRB1*11:01,HLA-DRB1*15:01, HLA-DRB1*04:05,HLA-DQA1*01:01/DQB1*05:01,HLA-DRB1*04:04 | 1.0248 | 1168–1182 |
| LSIGLFFLLIYLGRT | HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB5*01:01,HLA-DPA1*01/DPB1*04:01,HLA-DRB1*15:01,HLA-DRB1*11:01,HLA-DRB1*04:04,HLA-DRB1*04:05,HLA-DQA1*01:01/DQB1*05:01,HLA-DRB4*01:01,HLA-DPA1*02:01/DPB1*05:01 | 0.9860 | 1169–1183 |
| IGLFFLLIYLGRTGL | HLA-DRB1*01:01,HLA-DRB1*11:01,HLA-DRB1*15:01, HLA-DPA1*01/DPB1*04:01,HLA-DRB5*01:01, HLA-DRB1*04:04,HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DPA1*01:03/DPB1*02:01, HLA-DRB1*04:05, HLA-DRB4*01:01 | 1.0772 | 1171–1185 |
| GLFFLLIYLGRTGLS | HLA-DPA1*02:01/DPB1*01:01, HLA-DRB1*01:01,HLA-DRB1*11:01,HLA-DRB1*15:01,HLA-DRB5*01:01, HLA-DRB1*04:04,HLA-DPA1*03:01/DPB1*04:02,HLA-DPA1*01:03/DPB1*02:01, HLA-DPA1*01/DPB1*04:01,HLA-DRB1*04:05,HLA-DQA1*05:01/DQB1*03:01 | 1.1893 | 1172–1186 |
| SIGLFFLLIYLGRTG | HLA-DRB1*01:01,HLA-DRB1*15:01,HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*11:01, HLA-DRB1*04:05, HLA-DRB5*01:01,HLA-DPA1*01:03/DPB1*02:01,HLA-DPA1*01/DPB1*04:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*04:04, | 1.2425 | 1170–1184 |
| TILLICLYVALSIGL | HLA-DRB1*01:01,HLA-DRB1*07:01,HLA-DRB1*04:04,HLA-DRB1*15:01,HLA-DRB1*04:05,HLA-DRB1*09:01,HLA-DRB1*11:01,HLA-DRB1*13:02,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*04:01,HLA-DRB5*01:01,HLA-DRB4*01:01 | 1.2532 | 1159–1173 |
| LKTILLICLYVALSI | HLA-DPA1*03:01/DPB1*04:02, HLA-DRB1*07:01,HLA-DRB1*01:01,HLA-DRB1*04:04,HLA-DRB1*15:01, HLA-DRB1*04:05, HLA-DRB4*01:01,HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*13:02, HLA-DRB1*11:01, HLA-DRB1*04:01, | 0.9089 | 1157–1171 |
| KTILLICLYVALSIG | HLA-DRB1*01:01,HLA-DRB1*07:01,HLA-DRB1*04:04,HLA-DRB1*15:01,HLA-DRB1*04:05,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*04:01,HLA-DRB1*13:02,HLA-DRB1*11:01 | 1.1808 | 1158–1172 |
| PLKTILLICLYVALS | HLA-DRB1*01:01,HLA-DRB1*04:04,HLA-DRB1*15:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*04:05,HLA-DRB4*01:01,HLA-DPA1*02:01/DPB1*01:01,HLA-DRB1*11:01 | 0.7049 | 1156–1170 |
| GPLKTILLICLYVAL | HLA-DPA1*03:01/DPB1*04:02,HLA-DRB1*01:01,HLA-DRB1*15:01,HLA-DRB4*01:01, HLA-DRB1*04:04, HLA-DPA1*02:01/DPB1*01:01, | 0.5626 | 1155–1169 |
| ILLICLYVALSIGLF | HLA-DRB1*01:01,HLA-DRB1*07:01,HLA-DRB1*04:04,HLA-DRB1*15:01, HLA-DRB1*04:05,HLA-DRB1*09:01,HLA-DRB1*11:01,HLA-DRB5*01:01,HLA-DRB1*13:02,HLA-DRB1*04:01,HLA-DRB4*01:01 | 0.8879 | 1160–1174 |
| FFLLIYLGRTGLSKM | HLA-DRB1*11:01,HLA-DRB1*01:01,HLA-DRB1*15:01,HLA-DRB5*01:01,HLA-DQA1*05:01/DQB1*03:01 | 0.5873 | 1174–1188 |
| LFFLLIYLGRTGLSK | HLA-DRB1*01:01,HLA-DRB1*15:01,HLA-DRB1*11:01,HLA-DRB5*01:01, HLA-DRB1*04:04, HLA-DQA1*05:01/DQB1*03:01,HLA-DPA1*03:01/DPB1*04:02,HLA-DPA1*02:01/DPB1*01:01,HLA-DPA1*01:03/DPB1*02:01, | 0.6358 | 1173–1187 |
| LLICLYVALSIGLFF | HLA-DRB1*01:01,HLA-DRB1*07:01,HLA-DRB1*15:01,HLA-DRB1*09:01,HLA-DRB1*04:04,HLA-DRB1*04:05,HLA-DRB5*01:01,HLA-DRB1*13:02,HLA-DRB1*04:01,HLA-DRB1*11:01 | 1.0899 | 1161–1175 |