Table 2.

Biological relevance of single amino acid replacements in Arenavirus biology^a.

Amino acid substitution	Protein/virus	Biological effect
F260 → L/I	GP1/LCMV ARM → Cl13	Confer immunosuppressive phenotype (CTL−P+)
		Specific targeting of dendritic cells
		Increased affinity for α-DG receptor
S153 → F	GP1/LCMV (Wec54, Wec2.5)	Growth hormone deficiency syndrome (GHDS)
		Mediates LCMV WE GHDS− → GHDS+
		Abrogates targeting of dendritic cells

^aSummarized from Sevilla et al. (2002) and Sevilla and de la Torre (2006).