Figure 3.
p53 Regulates FBL Expression in Human Breast Cell Lines and Tumors
(A) Quantification of FBL mRNA expression analyzed by RT-qPCR and normalized to RNA18S.
(B) Quantification of FBL protein expression analyzed by western blot. All graphs represent mean and SD of at least three experiments.
(C) Box-and-whisker plots of FBL mRNA expression quantification in wild-type p53 (n = 59) versus mutant p53 (n = 21) primary breast tumor samples. The bottom and the top of the boxes represent the 25th and 75th percentiles, respectively. The median values are visible as a line, the mean as a cross in the box and SD as error bars. The p value has been determined by a Mann-Whitney W test.