Table 3.
Randomised controlled trials of inhaled corticosteroids used acutely for the management of episodic (viral wheeze)
Study | Inhaled corticosteroid | Duration (days) | Total daily dose (mcg) | Beclomethasone equivalent | Benefit | Harm |
---|---|---|---|---|---|---|
Bisgaard 200658 | Budesonide | 14 | 400 | 400 | No difference in symptom free days | No effect on height |
Svedmyr 199959 | Budesonide | 31 | 1600 | 1600 | Reduced symptom score | No effect on morning cortisol |
Wilson 199060 | Beclomethasone | 5 | 2250 | 2250 | Reduced symptom score | Not reported |
Ducharme 200957 | Fluticasone | </= 10 | 1500 | 3000 | 50% reduction in oral steroid use | Reduced height & weight velocity |
Connett 199361 | Budesonide | </= 14 | 32002 | 3200 | Reduced symptom score | Not reported |
1. Then budesonide 800 mcg daily for a further 7 days.
2. Children who were able to use the spacer device without a face mask were given 1600 mcg / day.