Table 2.

Antiviral marine natural products

Compound	Type*	Source	Activity	Reference
Papuamides A	Cyclic depsipeptides	Theonella mirabilis and T swinhoei sponges	HIV-1RF IC50 0·004μ g/mL	65
Avarone	Sesquiterpene hydroquinone	Dysidea avara sponge	HIV-1 0·1–1·0 μg/mL	66
Gymnochrome D	Brominated phenanthroperylenequinone igments	Fossil crinoid Gymnocrinus richeri	Dengue virus at doses <1·0 g/mL	67
Microspinosamide	Cyclic depsipeptide	Sidonops microspinosa sponge	HIV-1 EC50 0·2μg/mL	68
Solenolide A	Diterpene lactone	Gorgonian of the genus Solenopodium	Rhinovirus IC50 0·39μg/mL, poliovirus III, herpesvirus, and Ann Arbor and Maryland viruses	69
Hennoxazole A	Oxazole-containing alkaloid	Polyfibrospongia sp sponge	HSV1 IC50 0·6 μg/mL	70
Thyrsiferol	Triterpene	Red alga Laurencia venusta	VSV and HSV1 0·1–0·5 μg/disk	71
Spongiadiol	Tetracyclic furanoditerpene	Deep-water Spongia sp	HSV1 0·5 μg/disk	72

HSV1=herpes simplex virus 1; VSV=vesicular stomatitis virus.

^*Structures illustrated in figure 2.