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Niclosamide inhibits transcription of HIV in a T cell line. J-Lat cells were activated with 50 ng/mL PMA in media alone, or in the presence of increasing concentrations of niclosamide ranging from 0.3125 to 5 μM and assayed for the presence of GFP by flow cytometry. Niclosamide reduced proviral transcription in T cells from the live gate in a dose-dependent manner, with increasing drug-related toxicity observed in the total culture.
