Table 1.

Overview of therapeutic approaches in humans and animals [71], [72], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117].

Disease	Antigen	Effect	Authors
Bovine coronavirus	Inactivated bovine coronavirus	Passive protection in neonatal calves	Ikemori et al. [74]
Candida albicans	Candida ssp., C. albicans	Reduction of inherence and inhibition of biofolm formation	Fujibayashi et al. [75]
	C. albicans antigen	Protection against oral candidiasis in mice	Ibrahim et al. [76]
Cholera	Killed O1 and O139, rCTB	Protection in suckling mice	Hirai et al. [77]
Clostridium difficile	rColonization factor	Inhibition of adherence and protection from infection in hamsters	Mulvey et al. [78]
E. coli	Heat-extracted antigens from ETEC strain 431	Prevention of fatal bovine colibacillosis in neonatal calves	Ikemori et al. [79]
	E. coli B16-4, enterotoxin, colonization factor antigen I	Prevention of diarrhoea in rabbits	O'Farrely et al. [80]
	K88, K99, 987P fimbrial adhesions	Passive protection of neonatal pigs against fatal colibacillosis	Yokoyama et al. [81]
	F18ab-fimbriae	Reduction of diarrhoea and death in infected pigs	Imberechts et al. [82]
	Fimbrial antigens of ETEC K88+	Passive protection in neonatal pigs	Marquardt et al. [83]
	Bacterial suspension of EPEC	Recognition of several bacterial virulence factors	Amaral et al. [84]
	E. coli O78:K80	Improvement of intestinal health indices and immunological responses in chickens	Mahdavi et al. [85]
	ETEC K88+, fimbrial antigen	Reduction of diarrhoea in pigs	Li et al. [86]
	B subunit protein of Stx1	Protection from toxin challenges in mice	Wang et al. [87]
Glioma	Membrane fractions of rat C6 cells enriched in metalloproteolytic activity	Inhibition of spreading, migration and invasion of C6 cells in vitro	Hensel et al. [88]
Heliobacter pylori	Cell lysate, H. pylori 58 kDa antigen	Inhibition of infection in mice	Attallah et al. [89]
Human and bovine rotavirus	Purified human rotavirus	Prevention of development of gastroenteritis	Yolken et al. [90]
		Virus neutralization in suckling mice	Hatta et al. [91]
	Human group A rotavirus	Protection in suckling mice	Ebina et al. [92]
	Bovine rotavirus	Protection against homologous BRV in calves	Kuroki et al. [93]
Human enterovirus Type 71	Inactivated human EV71	Reduction of morbidity and mortality in infected mice	Liou et al. [94]
Infectious bursal disease virus	IBDV	Passive protection in chicks	Eterradossi et al. [95]
Inflammatory bowel disease	Tumour necrosis factor (TNF)	Reduction of inflammatory end points in rats	Worledge et al. [96]
Influenza	H5N1 virus vaccines, inactivated H1N1 virus	Protection from infection in mice	Nguyen et al. [97]
	Swine influenza virus vaccine	Neutralizing of virus A/H1N1	Tsukamoto et al. [98]
Listeria monocytogenes	L. monocytogenes	Growth inhibition	Sui et al. [99]
Malignant diseases	P110 purified from human stomach cancer MGC-803 cells	Recognition of gastrointestinal system cancers	Yang et al. [100]
P. aeruginosa	Mixture of formalin-treated pathogenic bacteria	Growth inhibition in vitro	Sugita-Konishi et al. [101]
	P. aeruginosa	Retention of specific IgY in human oral cavity	Carlander et al. [102]
		Prevention of PA colonization in humans	Kollberg et al. [71]
		Prevention of infection in humans	Nilsson et al. [103]
Porcine epidemic diarrhoea virus	Concentrated PEDV	Immunoprophylactic effect in piglets	Kweon et al. [104]
S. aureus	Mixture of formalin-treated pathogenic bacteria	Inhibition of production of enterotoxin A	Sugita-Konishi et al. [101]
	Staphylococcal enterotoxin B	Passive protection in mice and rhesus monkeys	LeClaire [105]
S. mutans	S. mutans MT8148 serotype c	Protection against dental caries in rats	Otake et al. [106]
		Mild reduction of S. mutans in human saliva	Hatta et al. [107]
	S. mutans glucan binding protein B	Protection against dental caries in rats	Smith et al. [108]
	Cell-associated glycosyltransferrases	Reduction of smooth surface lesions and sulcal surface caries	Kruger et al. [72]
Salmonella spp.	Fimbriae of SEF14	Passive protection in mice	Peralta et al. [109]
	S. thyphimurium and S. dublin	Protection in neonatal calves	Yokoyama et al. [110]
	S. enteritidis	Inhibition of adhesion and invasion of S.E.	Sugita-Konishi et al. [111]
	S. enteritidis and S. thyphimurium	In vitro binding and growth inhibition of bacterial cells	Lee et al. [112]
White spot syndrome virus	Inactivated WSSV and DNA	Protection in crayfish	Lu et al. [113]
Xenograft rejection	Alpha-Gal antigen epitopes and other porcine aortic endothelial cell antigens	Inhibition of pig-to-human xenograft rejection	Fryer et al. [114]
	Alpha-gal epitope	Protection against porcine xenograft rejections	Leventhal et al. [115]
Y. ruckeri	Formalin-killed cells of serovar 1 (RS1154) and serovar 2 (RS1153)	Passive protection in rainbow trouts	Lee et al. [116]