Table.
The recommended dose and duration of treatment and chemoprophylaxis for management of human infection of avian influenza A (H5N1) virus
| Duration |
Age groups (years) |
|||||
|---|---|---|---|---|---|---|
| 1–6 | 7–9 | 10–12 | 13–64 | ≥65 | ||
| Oseltamivir | ||||||
| Treatment | 5 days | Weight adjusted doses: | Weight adjusted doses: | Weight adjusted doses: | 75 mg twice daily | 75 mg twice daily |
| • 30 mg twice daily for ≤15 kg | • 30 mg twice daily for ≤15 kg | • 30 mg twice daily for ≤ 15 kg | ||||
| • 45 mg twice daily for >15–23 kg | • 45 mg twice daily for >15–23 kg | • 45 mg twice daily for >15–23 kg | ||||
| • 60 mg twice daily for >23–40 kg | • 60 mg twice daily for >23–40 kg | • 60 mg twice daily for >23–40 kg | ||||
| • 75 mg twice daily for >40 kg | • 75 mg twice daily for >40 kg | • 75 mg twice daily for >40 kg | ||||
| Prophylaxis | Begin as soon as exposure identified and continue for 7–10 days after last known exposure | Dose varies by child's weight as for treatment but administered once daily | Dose varies by child's weight as for treatment but administered once daily | Dose varies by child's weight as for treatment but administered once daily | 75 mg/day | 75 mg/day |
| Zanamivir | ||||||
| Treatment | 5 days | Not licensed for use | 10 mg (two inhalations) twice daily | 10 mg (two inhalations) twice daily | 10 mg (two inhalations) twice daily | 10 mg (two inhalations) twice daily |
| Prophylaxis | Begin as soon as exposure identified and continue for 7–10 days after last known exposure | 1–4 years: NA; 5–6 years: 10 mg (two inhalations) once daily | 10 mg (two inhalations) once daily | 10 mg (two inhalations) once daily | 10 mg (two inhalations) once daily | 10 mg (two inhalations) once daily |
| Amantadine | ||||||
| Treatment | 5 days | 5 mg/kg per day up to 150 mg in two divided doses | 5 mg/kg/day up to 150 mg in two divided doses | 100 mg twice daily | 100 mg twice daily | ≤100 mg/day |
| Prophylaxis | Begin as soon as exposure identified and continue for 7–10 days after last known exposure | 5 mg/kg per day up to 150 mg in two divided doses7 | 5 mg/kg per day up to 150 mg in two divided doses | 100 mg twice daily | 100 mg twice daily | ≤100 mg/day |
| Rimantadine | ||||||
| Treatment | 5 days | Not licensed for use | Not licensed for use | Not licensed for use | 100 mg twice daily | 100 mg/day |
| Prophylaxis | Begin as soon as exposure identified and continue for 7 days after last known exposure | 5 mg/kg per day up to 150 mg in two divided doses7 | 5 mg/kg per day up to 150 mg in two divided doses7 | 100 mg twice daily | 100 mg twice daily | 100 mg/day |
NA=not applicable.