Fig. 2.

Properties and functions of sPLA₂-IIE. (A) Lipidomic heat map profiling of phospholipids in LDL of Pla2g2e^−/− (KO) mice relative to Pla2g2e^+/+ (WT) mice fed a high-fat diet for 18 weeks. Most PE, PG, PI and PS molecular species were elevated in LDL of KO mice, suggesting that sPLA₂-IIE acts on these minor lipoprotein phospholipids with no apparent fatty acid selectivity [62]. (B) A schematic diagram of the sPLA₂-IIE-driven lipid pathway in lipoprotein metabolism during obesity. In obesity, sPLA₂-IIE is induced in adipocytes, hydrolyzes minor lipoprotein phospholipids, and promotes obesity and hyperlipidemia. The roles of lysophospholipids released by sPLA₂-IIE are unknown. (C) In situ hybridization of sPLA₂-IIE in mouse skin. Intense Pla2g2e signal are localized to hair follicles [55].