Fig. 2.

Calculated structure (using Autodock) for the interaction of ATA with ypoH. YpoH is a protein tyrosine phosphatase which is essential for virulence in the Yersinia pestis. It is known that the functionality of this protein is inhibited strongly by ATA molecule (Liang et al., 2003). This figure shows the 10 most possible confirmations of ypoH-ATA complexes. The border residues that have contact with ATA are highlighted in red. This region is structurally conserved between ypoH, m-calpain and SARS-CoV RdRps, and constituted mainly of anti-parallel β-strand-turn-β-strand hairpin structures. Below, the two dimensional chemical structure for ATA (C₂₂H₁₄O₉) was shown.