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. 2020 Mar 30;11:22. doi: 10.1186/s13229-020-00328-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Increased hippocampus asymmetry in the Mir146a^−/− brain at P30. Volume (±S.D.) of the hippocampus (a) of the mutant and WT mice as measured by brain MRI at P30. The surface area of each region was measured from MRI images at 100 μM apart (5 images for the hippocampus and 15 for the cortex) and reconstructed using Image J to obtain final volume. b Brain MRI showing coronal sections. White arrows point towards the hippocampi; the larger white arrow point towards the enlarged hippocampus in the mutant. c Graph showing the volumes difference between two hippocampal hemispheres in Mir146a^+/+ and Mir146a^−/− brains. *p < 0.05 by Student’s unpaired 2-tailed t test. On average, one hippocampus side is 15% larger than the other in Mir146a^−/− brains with random distribution (2 right > left and 2 left > right)