Table 1.
Correlation between the ratio of Wnt5a+CD68+/CD68+ macrophages and clinicopathologic parameters (n = 63)
| Parameters | n (%) | Wnt5a+CD68+/CD68+ ratio (n) | χ2 value | P value | |
|---|---|---|---|---|---|
| Low (n = 32) | High (n = 31) | ||||
| Gender | 0.024 | 0.877 | |||
| Male | 38 (60.32) | 19 | 19 | ||
| Female | 25 (39.68) | 13 | 12 | ||
| Age (years) | 1.905 | 0.167 | |||
| <60 | 29 (46.03) | 12 | 17 | ||
| ≥ 60 | 34 (53.97) | 20 | 14 | ||
| Tumor site | 0.013 | 0.910 | |||
| Colon | 35 (55.56) | 18 | 17 | ||
| Rectum | 28 (44.44) | 14 | 14 | ||
| Tumor size (cm) | 0.386 | 0.535 | |||
| <5 | 41 (65.08) | 22 | 19 | ||
| ≥ 5 | 22 (34.92) | 10 | 12 | ||
| Tumor grade | 1.932 | 0.165 | |||
| Poor | 38 (60.32) | 22 | 16 | ||
| Moderate/Well | 25 (39.68) | 10 | 15 | ||
| LVI | 5.773 | 0.016 | |||
| Absence | 30 (47.62) | 20 | 10 | ||
| Presence | 33 (52.38) | 12 | 21 | ||
| PNI | 1.905 | 0.167 | |||
| Absence | 34 (53.97) | 20 | 14 | ||
| Presence | 29 (46.03) | 12 | 17 | ||
| TI | 6.719 | 0.010 | |||
| T1–2 | 15 (23.81) | 12 | 3 | ||
| T3–4 | 48 (76.19) | 20 | 28 | ||
| LNM | 7.014 | 0.008 | |||
| N0–1 | 31 (49.21) | 21 | 10 | ||
| N2–3 | 32 (50.79) | 11 | 21 | ||
| TNM stage# | 9.908 | 0.002 | |||
| I/II | 33 (52.38) | 23 | 10 | ||
| III | 30 (47.62) | 9 | 21 | ||
| CEA (ng/ml) | 0.128 | 0.721 | |||
| <5 | 44 (69.84) | 23 | 21 | ||
| ≥ 5 | 19 (30.16) | 9 | 10 | ||
Notes: Bold indicates P < 0.05; #The 7th edition of the AJCC Cancer Staging Manual. Abbreviations: LVI Lymphovascular invasion; PNI Perineural invasion; TI, tumor invasion; LNM Lymph node metastasis; TNM Tumor-node-metastasis; CEA carcinoembryonic antigen; CD68 Cluster of differentiation 68; Wnt5a Wingless-type MMTV integration site family, member 5a