Table 2.
Univariate and multivariate analyses of clinicopathologic parameters associated with recurrence-free survival and overall survival
| Parameters | Recurrence-free survival | Overall survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Gender (Male vs. Female) | 0.782 | 0.391–1.564 | 0.488 | 0.67 | 0.321–1.400 | 0.287 | ||||||
| Age (≥60 years vs. <60 years) | 0.639 | 0.325–1.255 | 0.194 | 0.641 | 0.316–1.303 | 0.219 | ||||||
| Tumor site (Colon vs. Rectum) | 1.015 | 0.515–2.001 | 0.965 | 1.418 | 0.700–2.876 | 0.332 | ||||||
| Tumor size (<5 cm vs. ≥ 5 cm) | 1.255 | 0.627–2.512 | 0.521 | 1.474 | 0.721–3.016 | 0.288 | ||||||
| Tumor grade (Well vs Moderate vs Poor) | 1.755 | 0.894–3.446 | 0.102 | 1.263 | 0.623–2.564 | 0.517 | ||||||
| LVI (Absence vs. Presence) | 2.134 | 1.051–4.333 | 0.036 | 1.998 | 0.937–4.257 | 0.073 | 2.51 | 1.178–5.350 | 0.017 | 2.336 | 1.040–5.251 | 0.040 |
| PI (Absence vs. Presence) | 1.557 | 0.793–3.059 | 0.198 | 1.955 | 0.957–3.997 | 0.066 | ||||||
| TI (T1–2 vs. T3–4) | 2.288 | 1.299–4.029 | 0.004 | 1.335 | 0.686–2.597 | 0.394 | 1.926 | 1.094–3.390 | 0.023 | 1.104 | 0.562–2.168 | 0.774 |
| LNM (N0–1 vs. N2–3) | 1.464 | 1.070–2.002 | 0.017 | 0.648 | 0.366–1.147 | 0.136 | 1.387 | 1.001–1.921 | 0.049 | 0.630 | 0.348–1.139 | 0.126 |
| TNM stage# (I vs. II vs. III) | 3.423 | 1.702–6.887 | 0.001 | 5.133 | 1.246–21.156 | 0.024 | 2.884 | 1.428–5.823 | 0.003 | 4.693 | 1.101–20.011 | 0.037 |
| CEA (≥ 5 ng/ml vs. <5 ng/ml) | 0.791 | 0.377–1.657 | 0.533 | 0.529 | 0.227–1.231 | 0.14 | ||||||
| CD68+ macrophage (Low vs. High) | 1.785 | 0.901–3.537 | 0.097 | 1.465 | 0.722–2.975 | 0.29 | ||||||
| Wnt5a+CD68+ macrophage (Low vs. High) | 2.204 | 1.088–4.465 | 0.028 | 0.981 | 0.441–2.182 | 0.962 | 2.184 | 1.045–4.563 | 0.038 | 0.925 | 0.404–2.115 | 0.853 |
| Wnt5a+CD68+/CD68+ macrophage (Low vs. High) | 4.596 | 2.126–9.935 | < 0.001 | 2.698 | 1.110–6.559 | 0.029 | 4.347 | 1.934–9.772 | < 0.001 | 2.809 | 1.107–7.128 | 0.030 |
Notes: Bold indicates P < 0.05; #The 7th edition of the AJCC Cancer Staging Manual. Abbreviations: LVI Lymphovascular invasion; PNI Perineural invasion; TI Tumor invasion; LNM Lymph node metastasis; TNM, tumor-node-metastasis; CEA Carcinoembryonic antigen; CD68 Cluster of differentiation 68; Wnt5a Wingless-type MMTV integration site family, member 5a