Fig. 5.

Regulation of circVAPA on cell cycle progression, migration and invasion was mediated by miR-125a/CREB5 axis. a, b The expression levels of miR-125a and CREB5 were detected in CRC cell lines (HCT116 and LOVO) and human normal colon mucosal epithelial cell line (NCM460). c, d Cell cycle in G0/G1 phase was examined in HCT116 and LOVOcells transfected with si-con, si-circVAPA, si-circVAPA + anti-miR-con, si-circVAPA + anti-miR-125a, si-circVAPA + vector and si-circVAPA + CREB5. e, f Migratory ability was assessed in transfected HCT116 and LOVO cells. g, h Invasive capacity was tested in transfected HCT116 and LOVO cells. *P < 0.05