. 2020 Mar 30;10:49. doi: 10.1186/s13578-020-00412-4

Table 1.

Summary of all Brca1 mutant alleles

MGI allele ID	Allele symbol	Synonyms	Embryonic development phenotypes (homozygous)	References
Mice with complete disruption of BRCA1
MGI:1858108	Brca1 <tm1Mak>	Brca1^Δ5-6	Die before E7.5	[35]
MGI:2429692	Brca1 <tm2Mak>	Brca1^flox5-6	Conditional, viable	[38]
MGI:3762184	Brca1 <tm1.1Brn>	Brca1^Δ5-13	Embryonic lethal, embryonic development not analyzed	[39]
MGI:3696057	Brca1 <tm1Brn>	Brca1^flox5-13	Conditional, viable	[39]
Mice with Exon11 disruptions
MGI:1857931	Brca1 <tm1Bhk>	Brca1^Δ223-763	Die between E8.5 to E13.5	[40]
MGI:1930612	Brca1 <tm1Cxd>	Brca1¹¹⁻	Die between E7.5 and E9.5	[42]
MGI:1858107	Brca1 <tm1Whl>	Brca1^Δ300-361	Die before E7.5	[43]
MGI:2177209	Brca1 <tm2Arge>	Brca1^tr	Largely viable, viability depends on genetic background	[44]
MGI:2182470	Brca1 <tm2.1Cxd>	Brca1^Δ11	Seldomly viable, most die between E12.5–18.5	[45]
MGI:1931238	Brca1 <tm2Cxd>	Brca1^flox11	Conditional, viable	[45]
MGI:3665173	Brca1 <tm4Cxd>	Brca1^FL	Viable	[47]
Mice with RING domain disruptions
MGI:1930613	Brca1 <tm1Arge>	Brca1^ex2	Die between E6.5 and E9.5	[48]
MGI:3790741	Brca1 <tm1Thl>	Brca1^flex2	Conditional, viable	[49]
MGI:5823771	Brca1 <tm2Jjon>	Brca1^185stop	Die between E9.5 to E13.5	[50]
MGI:5307254	Brca1 <tm1.1Jjon>	Brca1^C61G	Die between E9.5 and E12.5	[51]
MGI:5494435	Brca1 <tm3.1Thl>	Brca1^I26A	Viable	[41]
Mice with BRCT domain disruptions
MGI:2178447	Brca1 <tm1Rfo>	Brca1^1700T	Die between E9.5 and E10.5	[53]
MGI:5823772	Brca1 <tm3Jjon>	Brca1^5382stop	Die between E9.5 and E12.5	[50]
MGI:3706167	Brca1 <tm1Aash>	Brca1^F22-24	Conditional, viable	[54]
MGI:6281370	Brca1 <em1Njo>	Brca1^ΔC	Embryonic lethal, embryonic development not analyzed	[56]
MGI:5494434	Brca1 <tm2.1Thl>	Brca1^S1598F	Viable	[41]
Mice with disrupted phosphorylation
MGI:3513253	Brca1 <tm3Cxd>	Brca1^S971A	Viable	[61]
MGI:4418211	Brca1 <tm5.1Cxd>	Brca1^S1152A	Viable	[62]