Table 2.

Summary of Brca1 mutant embryos with rescued survival or prolonged development after additional gene disruption

Brca1 mutant allele (homozygous)	Additional gene disruption	Embryonic development phenotypes	References
Rescue of embryonic development defects by compromising p53 signaling
Brca1Δ5-6	p53−/−	Prolong the survival of embryo from E7.5 to E9.5	[63]
Brca1Δ5-6	p21−/−	Prolong the survival of embryo from E7.5 to E9.5	[63]
Brca1ex2	p53−/−	Improve the morphology of embryos at E8.5 and E9.5	[48]
Brca111−	p53−/−	Extend the survival for 2 days	[42]
Brca1Δ223-763	p53−/−	Partially viable	[64]
Brca1Δ11	p53+/− or p53−/−	Fully viable	[45]
Brca1Δ11	Chk2+/−or Atm+/−	Partially viable	[67]
Brca1Δ11	Chk2−/− or Atm−/−	Fully viable	[67]
Rescue of embryonic lethality by 53bp1 KO
Brca1Δ11	H2ax−/− or Rnf8−/− or Rnf168−/−	Embryonic lethal, fail to rescue	[69, 80]
Brca1Δ11	53bp1−/−	Fully viable	[69]
Brca1Δ11	53bp1S25A/S25A	Fully viable	[83]
Brca1ex2	53bp1−/−	Fully viable	[71, 72]
Brca1ex2	Rnf168−/−	Fully viable	[80]
Brca1ΔC	53bp1−/−	Fully viable	[56]
Brca1Δ5-13	53bp1−/−	Partially viable	[82]