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. 2020 Mar 30;51:47. doi: 10.1186/s13567-020-00772-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fetal gene expression associated with regulation of cell cycle progression. Expression of genes responsible for promoting cell cycle progression (CCND1, CDK1, CDK2 and CDK4) and their inhibitor (CDKN1A) in the heart (A) and brain (B) tissue of fetuses derived from gestational day matched, non-inoculated control gilts (CON n = 10 heart and 12 brain) and from PRRSV2 challenged dams at 12 days post-inoculation and classified based on serum and thymic viral load as uninfected (UNIF n = 13 heart and 12 brain), high viral load viable (HV-VIA n = 8 heart and 12 brain) or high viral load meconium stained (HV-MEC n = 16 heart and 12 brain). Gene expression was determined by qPCR and fold changes were calculated relative to the average of the CON with unique superscripts denoting statistical differences (P < 0.05) within a given tissue and gene.