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. 2020 Mar 30;39:55. doi: 10.1186/s13046-020-01555-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Silencing circFOXM1 influences expression of cell cycle-related genes. a A volcano plot illustrated 685 differentially expressed genes in H1299 cells after silencing circFOXM1 by RNA sequencing analysis (|Fold change| > 2, FDR < 0.1). b A cluster heat map showed all 685 differentially expressed genes in H1299 cells after silencing circFOXM1. c Gene Set Enrichment Analysis (GSEA) indicated that the signatures of cell_cycle, cell_cycle_mitotic, mitotic G2_G2_M phase, and G1 phase were significantly enriched in circFOXM1 silencing group compared to control. NES: Normalized Enrichment Scores. d Validation of 6 cell cycle-related genes by qRT-PCR in H1299 and H2170 cells with circFOXM1 silencing. *P < 0.05