Table 2.

Effect of PPE on acetic acid-induced writhing test in mice

Treatment	Dose	No of writhing	% of writhing	% of writhing inhibition
Control (distilled water)	10 ml/kg	39.2 ± 1.3	100.0	0.0
Na diclofenac	10 mg/kg	13.4 ± 1.3*	34.2	65.8
PPE	100 mg/kg	35.8 ± 4.2*	91.3	8.7
PPE	250 mg/kg	24.0 ± 0.7*	61.2	38.8
PPE	500 mg/kg	18.2 ± 1.7*	46.4	53.6
PPE (500 mg/kg) + Naloxone (2 mg/kg)		13.5 ± 0.4*	34.4	65.6

N = 6. Values are mean ± SEM. *p < 0.05 compared to control (One-Way ANOVA followed by Dunnett’s post hoc test)