Table 1.
Characteristics of patients with spinal cord astrocytoma in this study
| Total | Total (Grade II–IV) | P-value | |||
|---|---|---|---|---|---|
| H3 wildtype | H3 K27M-mutant | ||||
| Number | 83 | 48 | 35 | ||
| Age (year) | Median | 31(6–63) | 30(6–63) | 35(9–52) | n.s |
| Gender | n.s | ||||
| male | 49(59%) | 31(65%) | 18(51%) | ||
| female | 34(41%) | 17(35%) | 17(49%) | ||
| Histological grade | 0.0068 | ||||
| II | 51(61%) | 37(77%) | 14(40%) | ||
| III | 20(24%) | 6(13%) | 14(40%) | ||
| IV | 12(14%) | 5(10%) | 7(20%) | ||
| Location | n.s | ||||
| C | 29(35%) | 19(40%) | 10(29%) | ||
| C-T | 13(16%) | 6(13%) | 7(20%) | ||
| T | 34(41%) | 19(40%) | 15(43%) | ||
| T-L | 7(8%) | 4(8%) | 3(9%) | ||
| Resection | < 0.0001 | ||||
| GTR | 50(60%) | 38(79%) | 12(34%) | ||
| STR | 16(19%) | 6(13%) | 10(29%) | ||
| OB | 17(20%) | 4(8%) | 13(37%) | ||
| Radio | n.s | ||||
| yes | 53(64%) | 30(63%) | 23(66%) | ||
| no | 18(22%) | 12(25%) | 6(17%) | ||
| unknown | 12(14%) | 6(13%) | 6(17%) | ||
| Chemo | 0.0484 | ||||
| yes | 23(28%) | 10(21%) | 13(37%) | ||
| no | 47(57%) | 32(67%) | 15(43%) | ||
| unknown | 13(16%) | 6(13%) | 7(20%) | ||
| IDH | n.s | ||||
| wildtype | 58(70%) | 33(69%) | 25(71%) | ||
| mutant | 0(0%) | 0(0%) | 0(0%) | ||
| unknown | 25(30%) | 15(31%) | 10(29%) | ||
| TERT promoter | n.s | ||||
| wildtype | 45(54%) | 24(50%) | 21(60%) | ||
| mutant | 13(16%) | 9(19%) | 4(11%) | ||
| unknown | 25(30%) | 15(31%) | 10(29%) | ||
| BRAF V600E | 0.0141 | ||||
| wildtype | 50(60%) | 26(54%) | 24(69%) | ||
| mutant | 7(8%) | 7(15%) | 0(0%) | ||
| unknown | 26(31%) | 15(31%) | 11(31%) | ||
| Ki-67 | < 0.0001 | ||||
| < 10% | 44(53%) | 37(63%) | 7(20%) | ||
| ≥10% | 46(55%) | 18(33%) | 28(80%) | ||
| unknown | 3(4%) | 3(4%) | 0(0%) | ||
| Survival (Median OS, months) | 40.13 | Und | 20.7 | < 0.0001 | |
C cervical vertebrae, C-T cervicothoracic vertebrae, T thoracic vertebrae, T-L thoracolumbar vertebrae, GTR gross total resection, STR subtotal resection, OB open biopsy, Radio Radiotherapy, Chemo Chemotherapy
Significant P-values are indicated in bold text