Table 2.
Comparison of immune cell abundance in osteoarthritis subchondral bones and osteoarthritis synovial tissues calculated by xCell and CIBERSORT algorithms.
| Cell type | xCell score | Correlation between xCell and CIBERSORT | Qualitative consistency xCell vs. CIBERSORT | ||
|---|---|---|---|---|---|
| Correlation coefficient | P value | ||||
| Subchondral bone | Neutrophils | 0.0039 ± 0.00175 | 0.602 | <0.001 | Yes |
|
| |||||
| Synovial tissue | Plasma cells | 0.0066 ± 0.00163 | 0.555 | <0.001 | Yes |
| Macrophage M1 | 0.0067 ± 0.00101 | -0.087 | 0.410 | No | |
| Macrophage M2 | 0.0071 ± 0.00120 | 0.233 | 0.026 | Yes | |
| Eosinophils | 0.0001 ± 0.00006 | 0.075 | 0.479 | Yes∗ | |
∗Qualitative consistency without statistical significance.