Table 5.
The interaction between rs3025010 and SNPs in the CCM3 gene.
| Variables | Unadjusted1 | Adjusted2 | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Additive model | ||||
| rs3025010 (TT)∗rs6784267 (CC) | Reference | |||
| rs3025010 (CT)∗rs6784267 (CT) | 0.699 (0.416, 1.172) | 0.174 | 0.642 (0.355, 1.160) | 0.142 |
| rs3025010 (CC)∗rs6784267 (CT) | 0.162 (0.036, 0.725) | 0.017∗ | 0.102 (0.018, 0.574) | 0.010∗ |
| rs3025010 (CT)∗rs6784267 (TT) | 1.111 (0.527, 2.342) | 0.782 | 1.086 (0.466, 2.530) | 0.849 |
| rs3025010 (CC)∗rs6784267 (TT) | 0.667 (0.111, 3.990) | 0.657 | 0.453 (0.053, 3.843) | 0.468 |
| Dominant model | ||||
| rs3025010 (TT)∗rs6784267 (CC) | Reference | |||
| rs3025010 (CT + CC) ∗ | ||||
| rs6784267 (CT + TT) | 0.678 (0.454, 1.013) | 0.058∗ | 0.574 (0.338, 0.973) | 0.039∗ |
| Recessive model | ||||
| rs3025010 (CT + TT) ∗ | ||||
| rs6784267 (CT + CC) | Reference | |||
| rs3025010 (CC) ∗ | ||||
| rs6784267 (TT) | 0.667 (0.111, 3.990) | 0.657 | 1.401 (0.167, 11.763) | 0.756 |
1OR and P values: unadjusted values in univariate analysis. 2OR and P values: multivariate analysis. We adjusted age, gender, BMI, smoking, drinking, and physical activity in all three models. Besides, rs833069, rs2146323, rs3212278, rs2305948, and rs7671745 were adjusted in the additive model; rs833061 and rs2146323 were adjusted in the dominant model; and rs833061, rs2146323, rs7667298, and rs10434 were adjusted in the recessive model. ∗P values have significance.