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A20 inhibits R/O ratio through downregulating autophagy under hypoxia. A, Cells were transfected with A20‐targeted lentivirus for overexpression and then treated in 2% O₂ for 24 h with or without autophagy inhibitor 3‐MA. The expression of A20, TRAF6, ATGs, and osteoclast‐related factors was detected by Western blot. B, LC3B was measured by IF (bar = 200 μm). C, Autophagosomes were observed by TEM (black arrows, bar = 2 μm and 1 μm)
