Figure 2.

Primary cilia functional protein IFT20 is required for cartilage matrix maintenance in condylar cartilage. A, Safranin O staining in the mandibular condyle of Ift20 conditional knockout mice (cKO) and wild‐type controls (WT). B, PCNA immunohistochemistry in Ift20 cKO and WT mice. C, The localization of IFT20 and the size of GM130 (cis‐Golgi marker) in condylar cartilage. D, Primary cilia and Hedgehog signalling‐related Smo protein expression in ATDC5 cells were transfected with si‐Ift20 and treated with Hedgehog agonist Purmorphamine (Puro) or Smoothened agonist (SAG). E, Primary cilia in the cartilage tissues of WT and Ift20 cKO mice. F, COL‐X expression in WT and Ift20 cKO mice. G, The potential mechanism of IFT20 is to regulate the Golgi size and Hedgehog signalling transduction to control the maintenance of the condylar cartilage. Reprinted with permission from Ref.67 Copyright 2019 Elsevier