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. 2020 Feb 5;53(3):e12773. doi: 10.1111/cpr.12773

Figure 7.

Figure 7

Res alleviated the disruption of the alveolar epithelial integrity through SIRT1/PTEN/p‐Akt pathway. A‐B, Effects of Res on SIRT1 expression in alveolar epithelial cells by Western blot. C‐E, Effects of Res on the protein expression of PTEN, Akt and p‐Akt in alveolar epithelial cells. F, The effects of Res on leakage of LDH from alveolar epithelial cells. A549 cells were pre‐treated with Res (1, 5, 20 μmol/L) for 1 h and then incubated with 5 mmol/L MA for 24 h. G‐I, Effects of Res on the protein expression of ZO‐1 and E‐cadherin in alveolar epithelial cells. Data are presented as the mean ± standard deviation.* P < .05 vs control group, # P < .05, ## P < .01 vs 5M group. 5M, 5 mmol/L methamphetamine; 20 Res, 20 μmol/L Resveratrol; 1R + 5M, 1 μmol/L Resveratrol and 5 mmol/L methamphetamine; 5R + 5M, 5 μmol/L Resveratrol and 5 mmol/L methamphetamine; 20R + 5M, 20 μmol/L Resveratrol and 5 mmol/L methamphetamine