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SPRR3 regulates EZH2 in NSCLC. (A) EZH2 and SPRR3 were positively correlated in TCGA data (n=1129). (B) Western blot confirmed that restoration of EZH2 by introducing a pLEX-EZH2 vector in PC9 cells. (C) Overexpression of EZH2 rescued the suppression effects on cell proliferation. EZH2 promotes the cell invasion after knockdown of SPRR3 (D and E). *p<0.05, **p<0.01 compared to corresponding controls.
