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. 2020 Mar 23;13:2411–2419. doi: 10.2147/OTT.S245422

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© 2020 Li et al.

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SPRR3 is a direct downstream target of miR-876-3p. (A) The binding site and sequence of miR-876-3p and SPRR3. (B) miR-876-3p mimics or scramble control and wild type or mutant SPRR3 3ʹUTR were co-transfected into PC9 cells. miR-876-3p reduced the luciferase activities with wild type 3ʹUTR but did not alter the luciferase activities with mutant 3ʹUTR. (C) miR-876-3p decreased endogenous SPRR3 and EZH2 protein levels in PC9 cells. **p<0.01.