Table 3.

Complete and Overall Response Rates, According to Cohort and Subgroup.

Variable	No. of Patients	Complete Response Rate*	Overall Response Rate
		percent of patients (95% CI)
All patients	116	20 (13–28)	79 (71–86)
Dose-escalation cohort	56	30 (19–44)	77 (64–87)
Expansion cohort	60	10 (4–21)	82 (70–91)
Age
≥70 yr	34	21 (9–38)	71 (53–85)
<70 yr	82	20 (12–30)	83 (73–90)
No. of previous therapies
≥4	56	16 (8–28)	73 (60–84)
<4	60	23 (13–36)	85 (73–93)
Fludarabine resistance
Yes	70	16 (8–26)	79 (67–88)
No	44	27 (15–43)	82 (67–92)
Bulky nodes of >5 cm
Yes	67	8 (3–17)	78 (66–87)
No	48	38 (24–53)	83 (70–93)
Chromosome 17p deletion
Yes	31	16 (6–34)	71 (52–86)
No	60	18 (10–30)	80 (68–89)
Chromosome 11q deletion
Yes	28	11 (2–28)	82 (63–94)
No	62	21 (12–33)	76 (63–86)
IGHV status
Unmutated	46	17 (8–31)	76 (61–87)
Mutated	17	29 (10–56)	94 (71–100)

^*A complete response includes complete remission with incomplete count recovery.