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. 2020 Mar 23;13:2399–2409. doi: 10.2147/OTT.S234230

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© 2020 Li et al.

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MiR-188 regulated ELF2 expression through binding to its 3ʹ UTRs. (A) The binding position of miR-188 in ELF2 was predicted by microT-CDS. Mutated sites were indicated as the red color. (B and C) Luciferase activity was determined in C666-1 (B) and 5-8F (C) cells transfected with ELF2-WT or ELF2-MUT and miR-188 or miR-con. (D and E) RIP assay was used to confirm the interaction between miR-188 and ELF2 in C666-1 (D) and 5-8F (E) cells. (F) The ELF2 mRNA was evaluated by qRT-PCR assay in NPC cells and normal cells. (G and H) The ELF2 protein level was detected in C666-1 (G) and 5-8F (H) cells transfected with miR-con, miR-188, in- miR-con or in-miR-188, respectively. **P<0.01 and ***P<0.001.