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. 2008 Jun 21;47(9):1299–1310. doi: 10.1093/rheumatology/ken225

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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Fig. 2. — Gelatin zymography of culture medium conditioned by monocytes/macrophages with CypA stimulation. The protein expression of pro-MMP-9 (d) and MMP-9 (e) were significantly increased when monocytes were differentiated into marophages. CypA increased the secretion and activation of pro-MMP-9, but not that of pro-MMP-2, in macrophages and monocytes/macrophages from RA SF. Both CSA and AP-9 could inhibit CypA's effect on MMP-9 production. Data are expressed as means ± s.d. (n = 8). *P < 0.05, **P < 0.05 vs negative control of monocytes and macrophages derived from normal human peripheral blood, respectively. P < 0.05, P < 0.05 vs negative control of monocytes and macrophages derived from RA patients’ peripheral blood; ★P < 0.05 vs negative control of monocytes/macrophages RA patients’ SF, respectively.

Inline graphic — Gelatin zymography of culture medium conditioned by monocytes/macrophages with CypA stimulation. The protein expression of pro-MMP-9 (d) and MMP-9 (e) were significantly increased when monocytes were differentiated into marophages. CypA increased the secretion and activation of pro-MMP-9, but not that of pro-MMP-2, in macrophages and monocytes/macrophages from RA SF. Both CSA and AP-9 could inhibit CypA's effect on MMP-9 production. Data are expressed as means ± s.d. (n = 8). *P < 0.05, **P < 0.05 vs negative control of monocytes and macrophages derived from normal human peripheral blood, respectively. P < 0.05, P < 0.05 vs negative control of monocytes and macrophages derived from RA patients’ peripheral blood; ★P < 0.05 vs negative control of monocytes/macrophages RA patients’ SF, respectively.