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. 2008 Jun 21;47(9):1299–1310. doi: 10.1093/rheumatology/ken225

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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Fig. 3. — Invasion assay of monocytes/macrophages with CypA stimulation. Monocytes and macrophages from normal human (a) and RA patients’ (b) peripheral blood were pre-treated, respectively with CSA, or AP-9, and then were stimulated by CypA for invasion assay. A higher number of macrophages (cells/filter) were found to have invaded through transwell chambers than monocytes. CypA significantly increased the number of the invading macrophages, while it had little effect on monocytes. CSA or AP-9 could inhibit CypA's function. Data are expressed as means ± s.d. (n = 8). *P < 0.05 and P < 0.05 vs negative control of monocytes and macrophages from normal human peripheral blood, respectively. *P < 0.05 and P < 0.05 vs negative control of monocytes and macrophages from RA patients’ peripheral blood, respectively.

Inline graphic — Invasion assay of monocytes/macrophages with CypA stimulation. Monocytes and macrophages from normal human (a) and RA patients’ (b) peripheral blood were pre-treated, respectively with CSA, or AP-9, and then were stimulated by CypA for invasion assay. A higher number of macrophages (cells/filter) were found to have invaded through transwell chambers than monocytes. CypA significantly increased the number of the invading macrophages, while it had little effect on monocytes. CSA or AP-9 could inhibit CypA's function. Data are expressed as means ± s.d. (n = 8). *P < 0.05 and P < 0.05 vs negative control of monocytes and macrophages from normal human peripheral blood, respectively. *P < 0.05 and P < 0.05 vs negative control of monocytes and macrophages from RA patients’ peripheral blood, respectively.