Skip to main content
. 2003 Jul;74(1):182–191. doi: 10.1093/toxsci/kfg107

TABLE 7 .

Dose-Response Analysis of Tissue Weights of Male Offspring at PND 49

Dose μg TEQ/kg
Tissue Control 1 Control 2a 0.05 0.2 0.8 1.0 2.0
Note. Values represent means ± SE (n = 8–10 males, each from different litters). All weights expressed in grams.
aControl 2 was run simultaneously with the 2.0 μg TEQ/kg group.
bNumbers in parentheses are organ wt./kg body weight.
*p < 0.05.
**p < 0.01.
***p < 0.001.
Body 276 ± 9 310 ± 12 274 ± 12 263 ± 9 271 ± 8 269 ± 13 279.4 ± 7.5*
Liver 15.65 ± 0.50 20.39 ± 0.88 15.72 ± 1.67 14.82 ± 0.72 16.17 ± 0.78 15.94 ± 0.98 16.98 ± 1.73*
(65.80 ± 3.00)b (62.44 ± 2.12)
Kidney 2.94 ± 0.09 3.23 ± 0.09 2.91 ± 0.17 2.78 ± 0.08 2.86 ± 0.11 2.95 ± 0.15 3.04 ± 0.12
Adrenals 0.05 ± 0.002 0.050 ± 0.003 0.05 ± 0.002 0.05 ± 0.003 0.05 ± 0.003 0.05 ± 0.002 0.05 ± 0.002
Spleen 0.76 ± 0.06 0.90 ± 0.04 0.85 ± 0.05 0.81 ± 0.02 0.78 ± 0.09 0.88 ± 0.03 0.84 ± 0.05
SV tissue 0.31 ± 0.02 0.33 ± 0.02 0.28 ± 0.02 0.30 ± 0.02 0.26 ± 0.02 0.29 ± 0.02 0.22 ± 0.02**
(1.07 ± 0.07) (0.81 ± 0.08)*
SV fluid 0.13 ± 0.01 0.16 ± 0.01 0.10 ± 0.01 0.11 ± 0.02 0.09 ± 0.02 0.12 ± 0.01 0.10 ± 0.02*
(0.53 ± 0.03) (0.35 ± 0.06)*
Total SV 0.43 ± 0.02 0.49 ± 0.24 0.38 ± 0.03 0.41 ± 0.03 0.36 ± 0.03 0.40 ± 0.03 0.32 ± 0.04**
(1.59 ± 0.08) (1.16 ± 0.14)**
Prostate 0.15 ± 0.01 0.17 ± 0.01 0.12 ± 0.01 0.11 ± 0.01** 0.09 ± 0.01** 0.11 ± 0.01* 0.08 ± 0.01***
(0.53 ± 0.04) (0.29 ± 0.03)***
Epidid. 0.36 ± 0.03 0.37 ± 0.01 0.31 ± 0.01 0.31 ± 0.02 0.32 ± 0.01 0.31 ± 0.01 0.32 ± 0.01*
(1.19 ± 0.04) (1.17 ± 0.04)
Testis 2.64 ± 0.14 2.78 ± 0.12 2.60 ± 0.07 2.60 ± 0.12 2.50 ± 0.10 2.44 ± 0.08 2.37 ± 0.10*
(8.99 ± 0.40) (8.55 ± 0.35)