TABLE 7 .
Dose-Response Analysis of Tissue Weights of Male Offspring at PND 49
Dose μg TEQ/kg | |||||||
---|---|---|---|---|---|---|---|
Tissue | Control 1 | Control 2a | 0.05 | 0.2 | 0.8 | 1.0 | 2.0 |
Note. Values represent means ± SE (n = 8–10 males, each from different litters). All weights expressed in grams. | |||||||
aControl 2 was run simultaneously with the 2.0 μg TEQ/kg group. | |||||||
bNumbers in parentheses are organ wt./kg body weight. | |||||||
*p < 0.05. | |||||||
**p < 0.01. | |||||||
***p < 0.001. | |||||||
Body | 276 ± 9 | 310 ± 12 | 274 ± 12 | 263 ± 9 | 271 ± 8 | 269 ± 13 | 279.4 ± 7.5* |
Liver | 15.65 ± 0.50 | 20.39 ± 0.88 | 15.72 ± 1.67 | 14.82 ± 0.72 | 16.17 ± 0.78 | 15.94 ± 0.98 | 16.98 ± 1.73* |
(65.80 ± 3.00)b | (62.44 ± 2.12) | ||||||
Kidney | 2.94 ± 0.09 | 3.23 ± 0.09 | 2.91 ± 0.17 | 2.78 ± 0.08 | 2.86 ± 0.11 | 2.95 ± 0.15 | 3.04 ± 0.12 |
Adrenals | 0.05 ± 0.002 | 0.050 ± 0.003 | 0.05 ± 0.002 | 0.05 ± 0.003 | 0.05 ± 0.003 | 0.05 ± 0.002 | 0.05 ± 0.002 |
Spleen | 0.76 ± 0.06 | 0.90 ± 0.04 | 0.85 ± 0.05 | 0.81 ± 0.02 | 0.78 ± 0.09 | 0.88 ± 0.03 | 0.84 ± 0.05 |
SV tissue | 0.31 ± 0.02 | 0.33 ± 0.02 | 0.28 ± 0.02 | 0.30 ± 0.02 | 0.26 ± 0.02 | 0.29 ± 0.02 | 0.22 ± 0.02** |
(1.07 ± 0.07) | (0.81 ± 0.08)* | ||||||
SV fluid | 0.13 ± 0.01 | 0.16 ± 0.01 | 0.10 ± 0.01 | 0.11 ± 0.02 | 0.09 ± 0.02 | 0.12 ± 0.01 | 0.10 ± 0.02* |
(0.53 ± 0.03) | (0.35 ± 0.06)* | ||||||
Total SV | 0.43 ± 0.02 | 0.49 ± 0.24 | 0.38 ± 0.03 | 0.41 ± 0.03 | 0.36 ± 0.03 | 0.40 ± 0.03 | 0.32 ± 0.04** |
(1.59 ± 0.08) | (1.16 ± 0.14)** | ||||||
Prostate | 0.15 ± 0.01 | 0.17 ± 0.01 | 0.12 ± 0.01 | 0.11 ± 0.01** | 0.09 ± 0.01** | 0.11 ± 0.01* | 0.08 ± 0.01*** |
(0.53 ± 0.04) | (0.29 ± 0.03)*** | ||||||
Epidid. | 0.36 ± 0.03 | 0.37 ± 0.01 | 0.31 ± 0.01 | 0.31 ± 0.02 | 0.32 ± 0.01 | 0.31 ± 0.01 | 0.32 ± 0.01* |
(1.19 ± 0.04) | (1.17 ± 0.04) | ||||||
Testis | 2.64 ± 0.14 | 2.78 ± 0.12 | 2.60 ± 0.07 | 2.60 ± 0.12 | 2.50 ± 0.10 | 2.44 ± 0.08 | 2.37 ± 0.10* |
(8.99 ± 0.40) | (8.55 ± 0.35) |