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. 2012 Oct 22;207(1):142–151. doi: 10.1093/infdis/jis653

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© The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Figure 1. — Permissiveness of primary murine brain glial cell cultures to NiV infection. Brain cultures from either wild-type (A, C, E) or IFNAR-KO mice (B, D, F) were mock-infected (A and B), or infected with NiV-EGFP (MOI = 1) and observed 48 h later under light (A–D) and fluorescent (E and F) microscope (×100). Formation of large multinuclear syncytia is indicated by arrows and presented in insert at higher (×300) magnification (C–F). Supernatants (G and H) and cells (I and J) from cultures obtained after NiV infection at MOI = 0.02 (G and I) or MOI = 1 (H and J) were taken at 24 and 48 h postinfection and titrated on Vero cells (G and H), and RNA was analyzed by RT-qPCR for the expression of IFN-I (I and J). Results are presented as average viral titers from triplicate cultures ± SD (G and H; *P < .01, Mann–Whitney U test) or no. of copies/μg of IFNß-specific RNA ± SD (I and J, **P < .01, ***P < .001; 2-way ANOVA test followed with Bonferroni post-test).