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. 2015 Jul 3;147(1):255–269. doi: 10.1093/toxsci/kfv127

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© The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

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FIG. 3. — Effects of polychlorinated biphenyl (PCB) 101, 153, and 180 alone (A–C) or in combination (D–F), on lipopolysaccharide (LPS)-induced mRNA expressions of IL-6 (panels A and D), TNFα (panels B and E), and MCP-1 (panels C and F). J774A.1 macrophages were exposed to PCBs at 300 nM, alone or mixed, in the presence of LPS (10 ng/ml) for 4 h. Therefore, cells were lysed for collection of RNA as described in Materials and Methods section. The mRNA expression levels were analyzed by real-time PCR. Data are means ± SEM of 3 independent experiments. As specified in the Materials and Methods section, when PCBs were used in combination, final concentration of pollutants was always 300 nM. **P < .01 and ***P < .001 versus untreated cells; ^#P < .05; ^##P < .01; and ^###P < .001 versus LPS-treated cells.