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. 2013 Nov 14;209(6):816–827. doi: 10.1093/infdis/jit603

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© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Figure 3. — Microscopic and immunohistochemical tissue images. Hematoxylin-eosin staining (A, C, and E) and subsequent immunohistochemical analysis reveal the presence of severe fever with thrombocytopenia syndrome virus (SFTSV) NP (B, D, F, G, H, I, and J) in the right axillary (A and B), right cervical (C and D), and the mediastinal (E and F) lymph nodes. A, C, and E, Infiltration by immunoblasts and prominent hemophagocytosis was generally observed in the right axillary, right cervical, mediastinal, hilar, and abdominal lymph nodes; however, necrosis was only observed in the right axillary and cervical lymph nodes. B, D, and F, Viral antigen–positive cells were detected in the right axillary and cervical lymph nodes. Positive signals for SFTSV NP antigen were detected in the cytoplasm of blastic cells (B; inset). Inset shows a higher magnification (40×). In contrast, no signals were detected in the mediastinal lymph nodes, regardless of immunoblast infiltration and hemophagocytosis. G, H, I, and J, Immunohistochemical analysis of SFTSV NP was performed in the bone marrow (G), adrenal glands (H), liver (I), and spleen (J). A few SFTSV antigen–positive cells were observed in these tissues, with no notable cytopathic effects or necrosis (magnification, 20×; inset, 40×).