Table 1.

Demographics and Clinical Features of the Study Population by Study Period

Variable	Pre-PCV Era 1999–2000	PCV7 Era 2001–2010	PCV13 Era 2011– 2014*	Total
(n)	(150)	(502)	(118)	(770)
Age (months) (n [%])
<24 Months	98 [65.3]	265 [52.8]	46 [38.9]	403 [52.3]
Gender (n [%])
Male	65 [43.3]	279 [55.6]	59 [50]	403 [52.3]
Race (n [%])
Black	60 [40]	125 [24.9]	29 [24.6]	214 [27.8]
Hispanic	37 [24.7]	174 [34.6]	49 [41.5]	260 [33.8]
White	49 [32.6]	170 [33.8]	29 [25.6]	248 [32.2]
Other	4 [2.7]	33 [6.7]	11 [9.3]	48 [6.2]
Diagnosis (n [%])
Isolated bacteremia	74 [49.3]	200 [39.8]	65 [55.1]	339 [44]
Pneumonia	38 [25.3]	159 [31.7]	20 [17]	217 [28.2]
Meningitis	22 [14.7]	83 [16.5]	20 [17]	125 [16.2]
Osteomuscular	9 [6]	16 [3.2]	6 [5]	31 [4]
Sinus/mastoid/ear	3 [2]	32 [6.6]	5 [4.2]	40 [5.2]
Peritonitis	3 [2]	10 [1.9]	2 [1.7]	15 [2]
Cardiovascular	1 [0.7]	2 [0.3]	0 [0]	3 [0.4]
Comorbidity (n [%])
Yes	49 [32.7]	212 [42.2]	68 [57.6]	329 [42.7]
Mortality (n [%])	6 [4]	23 [4.6]	6 [5.1]	35 [4.5]
Vaccine serotype (n [%])
PCV7	71 [47.4]	84 [16.7]	29 [24.4]	184 [23.9]
PCV13	17 [11.3]	239 [47.6]	47 [39.4]	303 [39.3]
Nonvaccine serotype	15 [10]	148 [29.5]	41 [34.5]	204 [26.5]
Nontypeable	0 [0]	17 [3.4]	2 [1.7]	19 [2.4]
Nonavailable	47 [31.3]	14 [2.8]	0 [0]	61 [7.9]

Abbreviations: IPD, invasive pneumococcal disease; PCV, pneumococcal conjugate vaccine.

*Until June 2014. In addition, in 2014, 2 different serotypes caused IPD in 1 patient.