Table 3.
Risk Factor Associations for Severe Disease Among Prospectively Studied HAdV-Positive Patients Hospitalized in Singapore, 2015–2018
| Total | Severe Diseasea | Unadjusted | Adjustedb | |
|---|---|---|---|---|
| Risk Factors | n = 233 (%) | n = 65 (%) | OR (95% CI) | OR (95% CI) |
| Gender | ||||
| Female | 98 (42.1) | 22 (33.8) | Reference | -- |
| Male | 135 (57.9) | 43 (66.2) | 1.6 (0.9–2.9) | -- |
| Age Quartiles (Q) | ||||
| ≤2.5 years (Q1) | 70 (30.2) | 18 (27.7) | Reference | -- |
| 3–4.5 years (Q2) | 48 (20.7) | 9 (13.8) | 0.7 (0.3–1.6) | -- |
| 5–43.5 years (Q3) | 56 (24.1) | 13 (20.0) | 0.9 (0.4–2.0) | -- |
| ≥44 years (Q4) | 58 (25.0) | 25 (38.5) | 2.2 (1.0–4.6) | -- |
| Immunocompromisedc | ||||
| Yes | 22 (9.4) | 17 (26.2) | 11.5 (4.0–32.9) | 11.4 (3.8–34.8) |
| No | 211 (90.6) | 48 (73.8) | Reference | Reference |
| HAdV genotype | ||||
| C1 | 6 (2.6) | 1 (1.5) | 1.5 (0.2–15.2) | 2.1 (0.2–21.4) |
| C2 | 8 (3.4) | 5 (7.7) | 12.9 (2.5–65.9) | 14.6 (2.7–80.4) |
| B3 | 61 (26.2) | 7 (10.8) | Reference | Reference |
| B7 | 44 (18.9) | 13 (20.0) | 3.2 (1.2–9.0) | 3.7 (1.2–10.9) |
| E4 | 60 (25.8) | 16 (24.6) | 2.8 (1.1–7.4) | 3.2 (1.1–8.9) |
| Unknownd | 47 (20.7) | 21 (32.3) | 6.2 (2.4–16.5) | 5.7 (2.0–16.2) |
| Othere | 7 (3.0) | 2 (3.1) | 3.1 (0.5–19.0) | 2.8 (0.4–20.4) |
Abbreviations: CI, confidence interval; HAdV, human adenovirus; OR, odds ratio.
aProlonged hospitalization, prolonged fever, or intensive care unit admission.
bAfter stepwise logistic regression using saturated model and backward elimination of covariates with P > .05.
cImmunocompromised within 6 months before clinical sample collection.
dGenotyping failed.
eHAdV-C5, -C6, -B11p, -B21, -B35, -D8, or -D53.