Table 4.
Risk Factor Associations for Severe Disease Among Prospectively Studied HAdV-Positive Pediatric Patients Hospitalized in Singapore, 2016–2018
| Total | Severe Diseasea | Unadjusted | Adjustedb | |
|---|---|---|---|---|
| Risk Factors | n = 151 (%) | n = 29 (%) | OR (95% CI) | OR (95% CI) |
| Gender | ||||
| Female | 57 (37.8) | 9 (31.0) | Reference | -- |
| Male | 94 (62.2) | 20 (69.0) | 1.4 (0.6–3.4) | -- |
| Age Group | ||||
| <1 years | 9 (6.0) | 4 (13.8) | 13.6 (1.2–151) | 17.9 (1.3–240) |
| 1–5 years | 115 (76.2) | 24 (82.8) | 4.5 (0.6–35.4) | 4.9 (0.5–46.4) |
| 6–10 years | 18 (12.0) | 1 (3.4) | Reference | Reference |
| 11–16 years | 8 (5.3) | -- | -- | -- |
| HAdV Genotype | ||||
| C1 | 4 (2.6) | 1 (3.4) | 2.8 (0.3–31.7) | 2.9 (0.3–32.4) |
| C2 | 6 (4.0) | 4 (13.8) | 17 (2.6–113.3) | 23.1 (3.1–173.3) |
| B3 | 57 (37.7) | 6 (20.7) | Reference | Reference |
| B7 | 32 (21.2) | 8 (27.6) | 2.8 (0.9–9.1) | 2.8 (0.9–9.3) |
| E4 | 38 (25.2) | 5 (17.2) | 1.3 (0.4–4.6) | 1.6 (0.4–5.9) |
| Unknownc | 10 (6.6) | 4 (13.8) | 5.7 (1.2–26.0) | 9.8 (1.7–56.3) |
| Otherd | 4 (2.6) | 1 (3.4)e | 2.8 (0.3–31.7) | 4.3 (0.3–55.3) |
Abbreviations: CI, confidence interval; HAdV, human adenovirus; OR, odds ratio.
aProlonged hospitalization, prolonged fever, or intensive care unit admission.
bAfter stepwise logistic regression using saturated model and backward elimination of covariates with P > .05.
cGenotyping failed.
dHAdV-C5, -B11p, or -D8.
eHAdV-C5.