Table 6.
Univariate and Multivariate Logistic Regression Analysesa to Assess the Association of Baseline Factors Present at Time of First RVI Onset With Subsequent Need for Respiratory Support, Pulmonary Complications, or Death
| Baseline Factor | Outcome Measure (OR [95% CI])c | |||
|---|---|---|---|---|
| All-Cause Deathd | Pulmonary Complicatione | |||
| Univariate Model | Multivariate Model | Univariate Model | Multivariate Model | |
| Age | 1.05 (0.91–1.22) | 1.31 (0.99 to 1.73) | 1.12 (0.98–1.27) | 1.24 (1.02–1.51) |
| Age category | ||||
| <2 years | Reference | Reference | ||
| 2 to <5 years | 2.78 (0.50–15.45) | 2.79 (0.50–15.45) | ||
| >5 years | 1.00 (0.10–10.47) | 2.17 (0.32–14.52) | ||
| Transplant type | ||||
| Heart/lung/heart–lung | Reference | Reference | Reference | Reference |
| Intestine/multiabdominal visceral | 14.0 (2.38–82.40) | 23.54 (1.69–327.96) | 2.65 (0.56–12.64) | 3.62 (0.46–28.44) |
| RVI onset within 60 days of SOT | 2.49 (0.51–12.11) | 0.93 (0.09–9.96) | 6.29 (1.17–33.81) | 2.49 (0.28–21.89) |
| Respiratory support at baselineb | 3.56 (0.72–17.47) | 6.71 (0.34–132.40) | 9.19 (1.68–50.14) | 7.99 (0.77–82.50) |
| Previous chronic lung disease | 0.80 (0.14–4.46) | 0.16 (0.01–2.63) | 1.26 (0.27–5.76) | 0.40 (0.05–3.42) |
| Received IVIg within 2 wk | 6.67 (1.30–34.06) | 6.01 (0.53–68.00) | 2.65 (0.56–12.64) | 2.22 (0.23–21.13) |
Abbreviations: CI, confidence interval; IVIg, intravenous immunoglobulin; OR, odds ratio; RVI, respiratory virus infection; SOT, solid organ transplant.
aAnalysis excluded renal and liver transplant recipients because no deaths occurred within 90 days after transplant in this patient population.
bIncludes at least 1 of the following: oxygen supplementation, bilevel positive airway pressure/continuous positive airway pressure, mechanical ventilation, and/or high-frequency oscillator ventilation/extracorporeal membrane oxygenation. For this model only the patients not requiring respiratory support at the time of RVI onset were considered.
cEach of the outcome measures was considered within 3 months of the onset of the first RVI event and represents an OR with the 95% CI. Multivariate logistic regression models each included age and race and any variable that had a P value of < .10 in univariate analysis.
dWithin 3 months of RVI onset.
ePumonary complications included at least 1 of the following: tracheostomy, subacute pulmonary sequalae, chronic pulmonary sequalae, bronchiolitis obliterans, and/or other pulmonary complications.