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. 2005 Mar 16;22(6):1444–1455. doi: 10.1093/molbev/msi132

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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

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FIG. 2.— — Schematic diagram of the transcription factor-catalyzed two-metal ion mechanism for the 3′–5′ exonuclease activity as proposed by Sosunova et al. (2003), extended to both the prokaryotic and eukaryotic polymerases.