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. 2007 May 2;24(8):1627–1638. doi: 10.1093/molbev/msm079

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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

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FIG. 5.— — The change of the affinity of the complex between Fab (A: HC45, B: BH151, C: HC19, D: HC63) and HA along the trunk-branches on the phylogenetic dendrogram of HA is shown by a solid line. The horizontal axis represents the number of amino acid substitutions of the contributing residues and background residues of HA reconstructed by the maximum-parsimony method. Several changes of the affinity on twig-branches are shown by dotted lines.