Table 2.

The Power of Eight Studies to Detect Various Binary Distinctions.

		EXB		U B		TiTv
Name	N	AUC	P value	AUC	P value	AUC	P value
Jacquier (TEM1)	757	0.66	2.8 × 10−14 **	0.61	4.0 × 10−8 **	0.54	0.019*
Rihn (HIV integrase)	156	0.64	2.1 × 10−3 **	0.67	7.2 × 10−5 **	0.54	0.191
Rihn (HIV capsid)	135	0.60	7.1 × 10−3 **	0.63	7.4 × 10−4 **	0.50	0.50
Carrasco (TEV)	52	0.64	0.037*	0.61	0.087	0.50	0.50
Peris (f1)	51	0.60	0.13	0.72	4.6 × 10−3 **	0.54	0.31
Domingo-Calap (Qbeta)	32	0.60	0.16	0.65	0.076	0.75	0.084
Sanjuan (VSV)	32	0.61	0.13	0.75	6.1 × 10−3 **	0.31	0.93
Domingo-Calap (phiX174)	24	0.81	5.8 × 10−3 **	0.94	1.6 × 10−4 **	0.34	0.85
Combined	1,239	0.65	6.5 × 10−18 **	0.64	1.6 × 10−12 **	0.53	0.024*

Note.—P values for a one-sided test where the alternative is that nominally conservative replacements, or transitions, are more fit. *P < 0.05; **P < 0.01.