Table 1.

ACE2 expression in glomeruli and renal tubules in diabetic nephropathy

	Glomeruli		Proximal tubules
	ACE2 mRNA	ACE2 protein	ACE2 mRNA	ACE2 protein	ACE2 activity
Human
Reich et al. [28]	↓	BD	↓	↓	NA
Lely et al. [29]	NA	↑	NA	↔	NA
Konoshita et al. [30]	NA	NA	↔	NA	NA
Mizuiri et al. [31]	↓	↓	↓	↓	NA
Animal models
Tikellis et al. [32] Streptozocin rats (Type 1 DM)	↑	↑	↓	↓	NA
Ye et al. [33]; Wyscocki et al. [34] db/db mice (Type 2 DM)	NA	↓	↔	↑	↑
Wysocki et al. [34] Streptozocin mice (Type 1 DM)	NA	NA	↔	↑	↑
Tikelis et al. [35] Streptozocin mice (Type 1 DM)	NA	NA	↓	↓	↑
Wong et al. [27] Akita mice (Type 1 DM)	NA	NA	↑	↑	NA

↓ = decreased; ↑ = increased; ↔ = no significant difference; NA = not analysed; BD = below detection.