Table 1.

The molecular divergence between SARS-CoV-2 and related viruses.

Gene	Aligned Length (nt)	RaTG13	GD Pangolin-CoV	GX Pangolin-CoV	SARSr-CoV ZC45	SARS-CoV	SARSr-CoV BM48–31
Genomic Average	28734	0.008/0.17 (0.044)	0.025/0.469 (0.053)	0.055/0.722 (0.076)	0.044/0.549 (0.081)	0.113/0.926 (0.122)	0.143/1.15 (0.124)
ORF10	114	0.011/0 (NA)	0.011/0 (NA)	0.072/0.044 (1.637)	0.011/0 (NA)	-	-
ORF3a	825	0.009/0.157 (0.06)	0.025/0.287 (0.086)	0.066/0.518 (0.128)	0.052/0.508 (0.102)	0.188/0.918 (0.205)	0.271/0.923 (0.294)
ORF6	183	0/0.098 (0)	0.014/0.217 (0.063)	0.038/0.491 (0.077)	0.027/0.173 (0.158)	0.191/0.913 (0.209)	0.393/1.512 (0.26)
ORF7a	363	0.011/0.177 (0.061)	0.018/0.275 (0.066)	0.073/0.477 (0.153)	0.066/0.351 (0.188)	0.088/0.697 (0.126)	0.337/1.14 (0.296)
ORF7b	129	0.01/0 (NA)	0.02/0.455 (0.043)	0.17/0.436 (0.39)	0.029/0.181 (0.162)	0.155/0.401 (0.387)	0.264/NA (NA)
ORF8	363	0.021/0.07 (0.303)	0.032/0.303 (0.105)	0.099/1.015 (0.098)	0.03/0.603 (0.05)	-	-
E	225	0/0.018 (0)	0/0.037 (0)	0.006/0.096 (0.063)	0/0.056 (0)	0.027/0.166 (0.164)	0.043/0.352 (0.121)
M	666	0.004/0.186 (0.021)	0.014/0.298 (0.046)	0.025/0.372 (0.067)	0.016/0.283 (0.055)	0.07/0.576 (0.121)	0.109/1.292 (0.085)
N	1257	0.005/0.131 (0.039)	0.012/0.149 (0.08)	0.04/0.304 (0.132)	0.036/0.333 (0.108)	0.059/0.381 (0.155)	0.102/1.197 (0.085)
orf1a	13215	0.009/0.167 (0.054)	0.024/0.475 (0.052)	0.073/0.811 (0.09)	0.026/0.405 (0.063)	0.148/1.141 (0.129)	0.174/1.199 (0.145)
orf1ab	21288	0.007/0.152 (0.044)	0.018/0.487 (0.037)	0.055/0.776 (0.071)	0.031/0.527 (0.058)	0.105/0.962 (0.109)	0.125/1.108 (0.113)
S (spike)	3819	0.014/0.321 (0.043)	0.076/0.7 (0.11)	0.06/0.86 (0.07)	0.138/1.063 (0.13)	0.172/1.265 (0.136)	0.217/1.518 (0.143)

For each gene, the dN and dS values between SARS-CoV-2 and another virus are given, and the dN/dS (ω) ratio is given in the parenthesis.