Table III.
Summary of the hub gene functions.
| No. | Gene symbol | Full name | Function | Degree |
|---|---|---|---|---|
| 1 | TOP2A | DNA topoisomerase II α | TOP2A functions as the target for various anticancer agents and mutations in it are associated with drug resistance | 31 |
| 2 | AURKA | Aurora kinase A | AUEKA plays a role in tumor development and progression | 22 |
| 3 | UBE2C | Ubiquitin conjugating enzyme E2 C | UBE2C is required for the destruction of mitotic cyclins and for cell cycle progression, and is involved in cancer progression | 20 |
| 4 | KIAA0101 (PCLAF) | PCNA clamp associated factor | PCNA-binding protein acts as a regulator of DNA repair during DNA replication | 20 |
| 5 | CDC20 | Cell division cycle 20 | CDC20 is a regulatory protein interacting with several other proteins at multiple points in the cell cycle | 19 |
| 6 | CCNB2 | Cyclin B2 | CCNB2 is one of the essential components of the cell cycle regulatory machinery | 18 |
| 7 | TK1 | Thymidine kinase 1 | High level of TK1 is used as a biomarker for diagnosing and categorizing many types of cancers | 17 |
| 8 | PTTG1 | Pituitary tumor-transforming 1 | PTTG1 product has transforming activity in vitro and tumori genic activity in vivo, and it is highly expressed in various tumors | 17 |
| 9 | MELK | Maternal embryonic leucine zipper kinase | Diseases associated with MELK include uterine corpus endometrial carcinoma. Among its related pathways are Neuroscience | 17 |
| 10 | NUSAP1 | Nucleolar and spindle associ ated protein 1 | NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization | 16 |
| 11 | CDC45 | Cell division cycle 45 | The protein encoded by CDC45 is an essential protein required for the initiation of DNA replication | 16 |
| 12 | ASPM | Abnormal spindle microtubule assembly | ASPM is essential for normal mitotic spindle function in embryonic neuroblasts | 16 |
| 13 | UBE2T | Ubiquitin conjugating enzyme E2 T | The protein encoded by UBE2T catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in UBE2T are associated with Fanconi anemia of complementation group T | 15 |
| 14 | CDCA5 | Cell division cycle associated 5 | Among its related pathways are Cell cycle, Mitotic and MicroRNAs in cancer | 15 |
| 15 | PRC1 | Protein regulator of cytokinesis 1 | PRV1 encodes a protein that is involved in cytokinesis which has been shown to be a substrate of several cyclin-dependent kinases | 14 |
| 16 | CDCA7 | Cell division cycle associated 7 | CDCA7 was identified as a c-Myc responsive gene. Overexpression of this gene enhances the transformation of lymphoblastoid cells | 13 |