Table III.
Cell inhibition rate after the combination of two drugs with various concentrations and at different ratios (mean ± SD, %).
| 17-AAG:Torin2 | ||||
|---|---|---|---|---|
| Concentration of Torin2 (µM) | 1:1 | 2:1 | t-valuea | P-value |
| 0.1 | 31.64±1.24 | 38.28±2.37 | 6.08 | <0.01 |
| 0.2 | 41.21±2.14 | 44.88±4.81 | 1.71 | 0.12 |
| 0.5 | 50.11±3.69 | 51.73±3.21 | 0.81 | 0.44 |
| 1 | 64.59±1.47 | 69.78±1.23 | 6.63 | <0.01 |
| 2 | 88.87±5.21 | 92.31±4.58 | 1.21 | 0.25 |
| 5 | 98.63±2.40 | 99.75±1.86 | 0.90 | 0.39 |
a
Analyzed by Student's t-test. 17-AAG, 17-allylamino-17-demethoxy-geldanamycin; Torin2, 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one.