Table 1.

Characteristics of 4 Patients With Hypogammaglobulinemia Treated With Pegylated Interferon α2a and Ribavirin

Age in y, Sex	Diagnosis, Age in y at Diagnosis	Comorbidities	Treatment	Trough Serum IgG Level, g/L^a	Previous RV RNA Detections, No.	RV RNA Shedding Duration in a Previous Episode, d^b	Treatment Date	Treated Symptom(s) of RV Infection	RV Shedding Duration Before, After Treatment	MxA Level Before, During Treatment, µg/L	Adverse Effect of Treatment	RV Negativity Duration After Ttreatment mo	New RV Episodes, Onset Date (RV Shedding Duration)
46, male	CVID, 24	ITP, AIHA, bronchiectasis, pulmonary nodules	IVIG	9.2	52	90	10 Oct 2011	Rhinorrhea	12 mo, 2 d	160, 1970	Mild flu-like symptoms	7 mo	15 Jun 2012 (8 wk), 28 Nov 2012 (5 wk)
45, male	CVID, 41	Pernicious anemia, vitiligo	SCIG	9.0	10	21	10 Nov 2012	Cough	0 wk, 3 d	20, 4710	None	2 mo	8 Jan 2013 (3 wk), 4 Oct 2013 (15 d)
59, male	CVID, 29	Pulmonary fibrosis, bronchiectasis	IVIG	7.6	25	57	23 Sep 2013	Cough, rhinorrhea	2 wk, 8 d	40, 400	Low fever	3 mo	19 Dec 2013 (5 wk)
49, male	XLA, 5	Bronchiectasis	SCIG	8.1	30	41	21 Nov 2011	Cough, rhinorrhea	6 wk, 7 d	30, 1220	Fever	6 mo	4 May 2012 (5 wk)

Abbreviations: AIHA, autoimmune hemolytic anemia; CVID, common variable immunodeficiency; IgG, immunoglobulin G; ITP, idiopathic thrombocytopenic purpura; IVIG, intravenous immunoglobulin; RV, rhinovirus; SCIG, subcutaneous immunoglobulin; XLA, X-linked agammaglobulinemia.

^a Mean trough level during a 2-year period.

^b Served as self-controls.