Table 1.

Some existing immunological databases reviewed in this article.

Database	Summary	URL	Refs
IMGT®	IMGT® is an integrated knowledge resource specialized in IG, TR, MHC, IG superfamily, MHC superfamily and related proteins of the immune system of human and other vertebrate species. IMGT® comprises 6 databases, 15 on-line tools for sequence, gene and 3D structure analysis, and more than 10,000 pages of resources Web. Data standardization, based on IMGT-ONTOLOGY, has been approved by WHO/IUIS	http://www.imgt.org/	[11]
SYFPEITHI	SYFPEITHI is a searchable database that contains more than 4500 records of MHC ligands and peptide motifs from humans and other species. Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are also available for a number of MHC allelic products	http://www.syfpeithi.de/	[5]
IEDB	IEDB is a resource center for data related to antibody and T cell epitopes for humans, non-human primates, rodents, and other animal species. T and B cell epitope prediction tools, epitope analysis tools, as well as peptide processing predictions are also available. As of January 2009, IEDB stores 5138 references, 115,906 records, 80,884 distinct structures, and 38,580 distinct epitopes	http://www.immuneepitope.org/	[10]
AntiJen	AntiJen contains over 24,000 entries of binding data on MHC ligands, TR-peptide-MHC complexes, T cell epitopes, TAP, B cell epitopes and immunological protein–protein interactions. Peptide library, copy numbers and diffusion coefficient data are also included	http://www.jenner.ac.uk/antijen/	[8]
MHCBN	MHCBN contains information on 20,717 MHC binders, 4022 MHC non-binders, 1053 TAP binders and non-binders, and 6722 T cell epitopes	http://www.imtech.res.in/raghava/mhcbn/	[7]
Los Alamos HIV databases	The Los Alamos HIV databases contain data on HIV sequences, 905 HIV-1 cytotoxic T cell epitopes, 1023 HIV-1 helper T cell epitopes, 1448 antibody-binding sites, drug resistance-associated mutations, and vaccine trials. The website also provides access to a large number of tools that can be used to analyze these data	http://www.hiv.lanl.gov/
IPD	IPD is a set of specialist databases related to the study of polymorphic genes in the immune system. It consists of four databases: IPD-KIR for sequences of killer-cell IG-like receptors; IPD-MHC for MHC sequences of different species; IPD-HPA for alloantigens expressed only on platelets; and IPD-ESTAB for access to the European Searchable Tumour Cell-Line Database, a cell bank of immunologically characterized melanoma cell lines	http://www.ebi.ac.uk/ipd/	[15]
Epitome	Epitome stores information of 142 antigens from protein–antibody complex structures	http://www.cubic.bioc.columbia.edu/services/Epitome/	[9]
Allergen Nomenclature Database	The Allergen Nomenclature Database contains information of allergens and isoallergens developed and maintained by the Allergen Nomenclature sub-committee of the IUIS. Data submissions are accepted and annotated by the committee members	http://www.allergen.org/	[17]
BIFS	BIFS contains information on 453 food allergens (64 animals, 389 plants), 645 non-food allergens, and 75 wheat gluten proteins	http://www.iit.edu/∼sgendel/fa.htm	[16]
SDAP	SDAP stores information of 887 allergenic proteins. It contains various tools for FAO/WHO allergenicity tests and assessing the IgE-binding potential of genetically modified food proteins	http://www.fermi.utmb.edu/SDAP/	[18]
FARRP	FARRP contains 1251 sequences of known and putative allergens derived from scientific literature and public databases	http://www.farrp.org/	[19]
Allergome	Allergome emphasizes the annotation of allergens that cause IgE-mediated disease. The database contains information derived from 5800 selected scientific literatures	http://www.allergome.org/	[20]