Table 3.
Comparison of TAC sensitivity in this and previous worka
| Virus | Characteristic | TAC assay—This Work | TAC assay—Kodani et alb |
|---|---|---|---|
| Adenovirus | No. true positives | 81 | 28 |
| % Sensitivity (95% CI) | 54 (43–65) | 97 (80–100) | |
| HMPV | No. true positives | 73 | 19 |
| % Sensitivity (95% CI) | 86 (76–93) | 95 (73–100) | |
| HPIV-1 | No. true positives | 16 | 7 |
| % Sensitivity (95% CI) | 56 (31–79)c | 100 (56–100) | |
| HPIV-2 | No. true positives | 4 | 11 |
| % Sensitivity (95% CI) | 75 (22–99) | 79 (49–94) | |
| HPIV-3 | No. true positives | 44 | 21 |
| % Sensitivity (95% CI) | 82 (67–91) | 95 (75–100) | |
| HPIV-4 | No. true positives | 12 | Not tested |
| % Sensitivity (95% CI) | 92 (60–99) | ||
| Influenza A | No. true positives | 115 | 22 |
| % Sensitivity (95% CI) | 95 (89–98) | 92 (72–99) | |
| Influenza B | No. true positives | 25 | 14 |
| % Sensitivity (95% CI) | 92 (72–99) | 100 (73–100) | |
| Rhinovirus | No. positives | 271 | 41 |
| % Sensitivity (95% CI) | 80 (75–84) | 98 (86–100) | |
| RSV | No. true positives | 201 | 30 |
| % Sensitivity (95% CI) | 94 (90–97) | 100 (86–100) |
a
Sensitivity of TAC assay for each work calculated assuming individual RT-qPCRtest results as “gold standard”.
b
FromKodani et al.2, with recalculated 95% CIs calculated by efficient-score method, corrected for continuity (see Methods).
c
Rose to 100% (95% CI 76–100) when new primer/probe set used—see text.